Outer retinal changes following acute optic neuritis

Omar A. Al-Louzi, Pavan Bhargava, Scott Newsome, Laura J. Balcer, Elliot M. Frohman, Ciprian M Crainiceanu, Peter Calabresi, Shiv Saidha

Research output: Contribution to journalArticle

Abstract

Background: Retinal nerve fiber and ganglion cell+inner plexiform (GCIP) layer thinning following multiple sclerosis-related acute optic neuritis (AON) is well described. However, whether AON results in changes in the inner nuclear (INL), outer plexiform (OPL), outer nuclear (ONL) and/or photoreceptor segment (PS) layers remains undetermined. Objectives: The objective of this paper is to determine if INL+OPL and/or ONL+PS changes occur following AON. Methods: Thirty-three AON patients underwent serial optical coherence tomography (OCT) and visual function testing (mean follow-up: 25 months). Longitudinal changes in retinal layer thickness were analyzed using mixed-effects linear regression. Results: Four months following AON, the mean decrease in GCIP thickness relative to baseline was 11.4% (p < 0.001). At four months, a concomitant 3.4% increase in average ONL+PS thickness was observed (p < 0.001). The percentage decrease in GCIP thickness and increase in ONL+PS thickness were strongly correlated (r =-0.70; p < 0.001). Between months 4 to 12, ONL+PS thickness declined and, at 12 months, was no longer significantly different from baseline (mean change: 0.5%; p = 0.37). Similar, albeit less robust, changes in the INL+OPL were observed. Conclusions: Following AON, dynamic changes occur in the deep retinal layers, which are proportional to GCIP thinning. These novel findings help further our understanding of the biological and/or anatomical sequelae resulting from AON.

Original languageEnglish (US)
Pages (from-to)362-372
Number of pages11
JournalMultiple Sclerosis
Volume22
Issue number3
DOIs
StatePublished - 2016

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Optic Neuritis
Ganglia
Optical Coherence Tomography
Nerve Fibers
Multiple Sclerosis
Linear Models

Keywords

  • Multiple sclerosis
  • Optic nerve injuries
  • Optic neuritis
  • Optical coherence tomography
  • Retinal ganglion cells
  • Retinal photoreceptors

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Outer retinal changes following acute optic neuritis. / Al-Louzi, Omar A.; Bhargava, Pavan; Newsome, Scott; Balcer, Laura J.; Frohman, Elliot M.; Crainiceanu, Ciprian M; Calabresi, Peter; Saidha, Shiv.

In: Multiple Sclerosis, Vol. 22, No. 3, 2016, p. 362-372.

Research output: Contribution to journalArticle

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abstract = "Background: Retinal nerve fiber and ganglion cell+inner plexiform (GCIP) layer thinning following multiple sclerosis-related acute optic neuritis (AON) is well described. However, whether AON results in changes in the inner nuclear (INL), outer plexiform (OPL), outer nuclear (ONL) and/or photoreceptor segment (PS) layers remains undetermined. Objectives: The objective of this paper is to determine if INL+OPL and/or ONL+PS changes occur following AON. Methods: Thirty-three AON patients underwent serial optical coherence tomography (OCT) and visual function testing (mean follow-up: 25 months). Longitudinal changes in retinal layer thickness were analyzed using mixed-effects linear regression. Results: Four months following AON, the mean decrease in GCIP thickness relative to baseline was 11.4{\%} (p < 0.001). At four months, a concomitant 3.4{\%} increase in average ONL+PS thickness was observed (p < 0.001). The percentage decrease in GCIP thickness and increase in ONL+PS thickness were strongly correlated (r =-0.70; p < 0.001). Between months 4 to 12, ONL+PS thickness declined and, at 12 months, was no longer significantly different from baseline (mean change: 0.5{\%}; p = 0.37). Similar, albeit less robust, changes in the INL+OPL were observed. Conclusions: Following AON, dynamic changes occur in the deep retinal layers, which are proportional to GCIP thinning. These novel findings help further our understanding of the biological and/or anatomical sequelae resulting from AON.",
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AU - Bhargava, Pavan

AU - Newsome, Scott

AU - Balcer, Laura J.

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AU - Calabresi, Peter

AU - Saidha, Shiv

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N2 - Background: Retinal nerve fiber and ganglion cell+inner plexiform (GCIP) layer thinning following multiple sclerosis-related acute optic neuritis (AON) is well described. However, whether AON results in changes in the inner nuclear (INL), outer plexiform (OPL), outer nuclear (ONL) and/or photoreceptor segment (PS) layers remains undetermined. Objectives: The objective of this paper is to determine if INL+OPL and/or ONL+PS changes occur following AON. Methods: Thirty-three AON patients underwent serial optical coherence tomography (OCT) and visual function testing (mean follow-up: 25 months). Longitudinal changes in retinal layer thickness were analyzed using mixed-effects linear regression. Results: Four months following AON, the mean decrease in GCIP thickness relative to baseline was 11.4% (p < 0.001). At four months, a concomitant 3.4% increase in average ONL+PS thickness was observed (p < 0.001). The percentage decrease in GCIP thickness and increase in ONL+PS thickness were strongly correlated (r =-0.70; p < 0.001). Between months 4 to 12, ONL+PS thickness declined and, at 12 months, was no longer significantly different from baseline (mean change: 0.5%; p = 0.37). Similar, albeit less robust, changes in the INL+OPL were observed. Conclusions: Following AON, dynamic changes occur in the deep retinal layers, which are proportional to GCIP thinning. These novel findings help further our understanding of the biological and/or anatomical sequelae resulting from AON.

AB - Background: Retinal nerve fiber and ganglion cell+inner plexiform (GCIP) layer thinning following multiple sclerosis-related acute optic neuritis (AON) is well described. However, whether AON results in changes in the inner nuclear (INL), outer plexiform (OPL), outer nuclear (ONL) and/or photoreceptor segment (PS) layers remains undetermined. Objectives: The objective of this paper is to determine if INL+OPL and/or ONL+PS changes occur following AON. Methods: Thirty-three AON patients underwent serial optical coherence tomography (OCT) and visual function testing (mean follow-up: 25 months). Longitudinal changes in retinal layer thickness were analyzed using mixed-effects linear regression. Results: Four months following AON, the mean decrease in GCIP thickness relative to baseline was 11.4% (p < 0.001). At four months, a concomitant 3.4% increase in average ONL+PS thickness was observed (p < 0.001). The percentage decrease in GCIP thickness and increase in ONL+PS thickness were strongly correlated (r =-0.70; p < 0.001). Between months 4 to 12, ONL+PS thickness declined and, at 12 months, was no longer significantly different from baseline (mean change: 0.5%; p = 0.37). Similar, albeit less robust, changes in the INL+OPL were observed. Conclusions: Following AON, dynamic changes occur in the deep retinal layers, which are proportional to GCIP thinning. These novel findings help further our understanding of the biological and/or anatomical sequelae resulting from AON.

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