Outer retina changes on optical coherence tomography in vitamin A deficiency

Meghan Berkenstock, Charles J. Castoro, Andrew R. Carey

Research output: Contribution to journalArticle

Abstract

Background: Vitamin A deficiency is rare in the United States and can be missed in patients with malabsorption syndromes without a high dose of suspicion. Ocular complications of hypovitaminosis A include xerosis and nyctalopia, and to a lesser extent reduction in visual acuity and color vision. Outer retinal changes, as seen on spectral domain optic coherence tomography (SD-OCT), in patients with vitamin A deficiency have previously not been documented. Case presentation: We present two cases with symptoms of severe nyctalopia who were subsequently diagnosed with severe Vitamin A deficiency and their unique findings on SD-OCT of outer nuclear layer diffuse thinning with irregular appearance of the interdigitating zone and the ellipsoid zone as well as normalization after vitamin A supplementation. Conclusions: Outer nuclear layer thinning and disruption of the outer retinal bands on SD-OCT are reversible with correction of vitamin A deficiency. Improvement in visual acuity, color vision, and nyctalopia are possible with early diagnosis and appropriate treatment.

Original languageEnglish (US)
Article number23
JournalInternational Journal of Retina and Vitreous
Volume6
Issue number1
DOIs
StatePublished - Jun 5 2020

Keywords

  • Nyctalopia
  • Optical coherence tomography
  • Vitamin A deficiency

ASJC Scopus subject areas

  • Ophthalmology

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