Outcomes of repeat mitral valve surgery in patients with pulmonary hypertension

Mario Castillo-Sang, Tracey J. Guthrie, Marc R. Moon, Jennifer Lawton, Hersh S. Maniar, Ralph J. Damiano, Scott C. Silvestry

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: We sought to study the outcomes of redo-mitral valve surgery in patients with pulmonary hypertension.

METHODS: We reviewed data on redo mitral valve surgery in patients with pulmonary hypertension measured by Swan-Ganz catheter (mean pulmonary artery pressure ≥ 25 mm Hg or systolic pulmonary artery pressure ≥ 40 mm Hg).

RESULTS: Between 1996 and 2010, 637 patients underwent 658 redo mitral valve operations; 138 of them had pulmonary hypertension. The mean patient age was 61.3 (13.9) years, with mean left ventricular ejection fraction of 47.6% (13.2%). The mean systolic pulmonary artery pressure was 61.5 (16.8) mm Hg, and mean pulmonary artery pressure was 40.8 (11.6) mm Hg. Patients had one (71%, 98/138), two (23.9%, 33/138), and three (5.1%, 7/138) previous mitral valve operations. Thirty-day mortality was 10.1% (14/138). Multivariate predictors of 30-day mortality were chronic renal failure [odds ratio (OR), 8.041; P = 0.022], peripheral vascular disease (OR, 5.976; P = 0.025), previous mitral valve replacement (OR, 9.034; P = 0.014), and increasing age (OR, 1.077; P = 0.013). The severity of pulmonary hypertension did not impact 30-day (P = 0.314) or late mortality (P = 0.860). Kaplan-Meier survival rates at 1, 3, and 5 years were 76.6% (n = 99), 65.7% (n = 62), and 55.9% (n = 41), respectively.

CONCLUSIONS: Patients with pulmonary hypertension that undergo redo mitral valve surgery have a 55.9% 5-year survival rate. Increasing age, chronic renal insufficiency, peripheral vascular disease, and preexisting mitral valve prosthesis are associated with early mortality. The severity of pulmonary hypertension does not affect operative mortality rates, but it may decrease 1-, 3-, and 5-year survival.

Original languageEnglish (US)
Pages (from-to)120-124
Number of pages5
JournalInnovations (Philadelphia, Pa.)
Volume10
Issue number2
DOIs
StatePublished - Mar 1 2015
Externally publishedYes

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Mitral Valve
Pulmonary Hypertension
Pulmonary Artery
Odds Ratio
Mortality
Pressure
Peripheral Vascular Diseases
Survival Rate
Chronic Renal Insufficiency
Stroke Volume
Chronic Kidney Failure
Prostheses and Implants
Catheters
Outcome Assessment (Health Care)
Survival

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Castillo-Sang, M., Guthrie, T. J., Moon, M. R., Lawton, J., Maniar, H. S., Damiano, R. J., & Silvestry, S. C. (2015). Outcomes of repeat mitral valve surgery in patients with pulmonary hypertension. Innovations (Philadelphia, Pa.), 10(2), 120-124. https://doi.org/10.1097/IMI.0000000000000139

Outcomes of repeat mitral valve surgery in patients with pulmonary hypertension. / Castillo-Sang, Mario; Guthrie, Tracey J.; Moon, Marc R.; Lawton, Jennifer; Maniar, Hersh S.; Damiano, Ralph J.; Silvestry, Scott C.

In: Innovations (Philadelphia, Pa.), Vol. 10, No. 2, 01.03.2015, p. 120-124.

Research output: Contribution to journalArticle

Castillo-Sang, M, Guthrie, TJ, Moon, MR, Lawton, J, Maniar, HS, Damiano, RJ & Silvestry, SC 2015, 'Outcomes of repeat mitral valve surgery in patients with pulmonary hypertension', Innovations (Philadelphia, Pa.), vol. 10, no. 2, pp. 120-124. https://doi.org/10.1097/IMI.0000000000000139
Castillo-Sang, Mario ; Guthrie, Tracey J. ; Moon, Marc R. ; Lawton, Jennifer ; Maniar, Hersh S. ; Damiano, Ralph J. ; Silvestry, Scott C. / Outcomes of repeat mitral valve surgery in patients with pulmonary hypertension. In: Innovations (Philadelphia, Pa.). 2015 ; Vol. 10, No. 2. pp. 120-124.
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abstract = "OBJECTIVE: We sought to study the outcomes of redo-mitral valve surgery in patients with pulmonary hypertension.METHODS: We reviewed data on redo mitral valve surgery in patients with pulmonary hypertension measured by Swan-Ganz catheter (mean pulmonary artery pressure ≥ 25 mm Hg or systolic pulmonary artery pressure ≥ 40 mm Hg).RESULTS: Between 1996 and 2010, 637 patients underwent 658 redo mitral valve operations; 138 of them had pulmonary hypertension. The mean patient age was 61.3 (13.9) years, with mean left ventricular ejection fraction of 47.6{\%} (13.2{\%}). The mean systolic pulmonary artery pressure was 61.5 (16.8) mm Hg, and mean pulmonary artery pressure was 40.8 (11.6) mm Hg. Patients had one (71{\%}, 98/138), two (23.9{\%}, 33/138), and three (5.1{\%}, 7/138) previous mitral valve operations. Thirty-day mortality was 10.1{\%} (14/138). Multivariate predictors of 30-day mortality were chronic renal failure [odds ratio (OR), 8.041; P = 0.022], peripheral vascular disease (OR, 5.976; P = 0.025), previous mitral valve replacement (OR, 9.034; P = 0.014), and increasing age (OR, 1.077; P = 0.013). The severity of pulmonary hypertension did not impact 30-day (P = 0.314) or late mortality (P = 0.860). Kaplan-Meier survival rates at 1, 3, and 5 years were 76.6{\%} (n = 99), 65.7{\%} (n = 62), and 55.9{\%} (n = 41), respectively.CONCLUSIONS: Patients with pulmonary hypertension that undergo redo mitral valve surgery have a 55.9{\%} 5-year survival rate. Increasing age, chronic renal insufficiency, peripheral vascular disease, and preexisting mitral valve prosthesis are associated with early mortality. The severity of pulmonary hypertension does not affect operative mortality rates, but it may decrease 1-, 3-, and 5-year survival.",
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AU - Castillo-Sang, Mario

AU - Guthrie, Tracey J.

AU - Moon, Marc R.

AU - Lawton, Jennifer

AU - Maniar, Hersh S.

AU - Damiano, Ralph J.

AU - Silvestry, Scott C.

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N2 - OBJECTIVE: We sought to study the outcomes of redo-mitral valve surgery in patients with pulmonary hypertension.METHODS: We reviewed data on redo mitral valve surgery in patients with pulmonary hypertension measured by Swan-Ganz catheter (mean pulmonary artery pressure ≥ 25 mm Hg or systolic pulmonary artery pressure ≥ 40 mm Hg).RESULTS: Between 1996 and 2010, 637 patients underwent 658 redo mitral valve operations; 138 of them had pulmonary hypertension. The mean patient age was 61.3 (13.9) years, with mean left ventricular ejection fraction of 47.6% (13.2%). The mean systolic pulmonary artery pressure was 61.5 (16.8) mm Hg, and mean pulmonary artery pressure was 40.8 (11.6) mm Hg. Patients had one (71%, 98/138), two (23.9%, 33/138), and three (5.1%, 7/138) previous mitral valve operations. Thirty-day mortality was 10.1% (14/138). Multivariate predictors of 30-day mortality were chronic renal failure [odds ratio (OR), 8.041; P = 0.022], peripheral vascular disease (OR, 5.976; P = 0.025), previous mitral valve replacement (OR, 9.034; P = 0.014), and increasing age (OR, 1.077; P = 0.013). The severity of pulmonary hypertension did not impact 30-day (P = 0.314) or late mortality (P = 0.860). Kaplan-Meier survival rates at 1, 3, and 5 years were 76.6% (n = 99), 65.7% (n = 62), and 55.9% (n = 41), respectively.CONCLUSIONS: Patients with pulmonary hypertension that undergo redo mitral valve surgery have a 55.9% 5-year survival rate. Increasing age, chronic renal insufficiency, peripheral vascular disease, and preexisting mitral valve prosthesis are associated with early mortality. The severity of pulmonary hypertension does not affect operative mortality rates, but it may decrease 1-, 3-, and 5-year survival.

AB - OBJECTIVE: We sought to study the outcomes of redo-mitral valve surgery in patients with pulmonary hypertension.METHODS: We reviewed data on redo mitral valve surgery in patients with pulmonary hypertension measured by Swan-Ganz catheter (mean pulmonary artery pressure ≥ 25 mm Hg or systolic pulmonary artery pressure ≥ 40 mm Hg).RESULTS: Between 1996 and 2010, 637 patients underwent 658 redo mitral valve operations; 138 of them had pulmonary hypertension. The mean patient age was 61.3 (13.9) years, with mean left ventricular ejection fraction of 47.6% (13.2%). The mean systolic pulmonary artery pressure was 61.5 (16.8) mm Hg, and mean pulmonary artery pressure was 40.8 (11.6) mm Hg. Patients had one (71%, 98/138), two (23.9%, 33/138), and three (5.1%, 7/138) previous mitral valve operations. Thirty-day mortality was 10.1% (14/138). Multivariate predictors of 30-day mortality were chronic renal failure [odds ratio (OR), 8.041; P = 0.022], peripheral vascular disease (OR, 5.976; P = 0.025), previous mitral valve replacement (OR, 9.034; P = 0.014), and increasing age (OR, 1.077; P = 0.013). The severity of pulmonary hypertension did not impact 30-day (P = 0.314) or late mortality (P = 0.860). Kaplan-Meier survival rates at 1, 3, and 5 years were 76.6% (n = 99), 65.7% (n = 62), and 55.9% (n = 41), respectively.CONCLUSIONS: Patients with pulmonary hypertension that undergo redo mitral valve surgery have a 55.9% 5-year survival rate. Increasing age, chronic renal insufficiency, peripheral vascular disease, and preexisting mitral valve prosthesis are associated with early mortality. The severity of pulmonary hypertension does not affect operative mortality rates, but it may decrease 1-, 3-, and 5-year survival.

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