Outcomes of preterm infants: Morbidity replaces mortality

Marilee C. Allen, Elizabeth A. Cristofalo, Christina Kim

Research output: Contribution to journalReview articlepeer-review


Over the last 50 years in the United States a rising preterm birth rate, a progressive decrease in preterm mortality, and a lowering of the limit of viability have made preterm birth a significant public health problem. Neuromaturation, the functional development of the central nervous system (CNS), is a dynamic process that promotes and shapes CNS structural development. This article reviews preterm outcomes, recognizing that multiple factors influence neuromaturation and lead to a range of neurodevelopmental disabilities, dysfunctions, and altered CNS processing. Ways to protect preterm infants and support their growth and development in and beyond intensive care are examined.

Original languageEnglish (US)
Pages (from-to)441-454
Number of pages14
JournalClinics in Perinatology
Issue number3
StatePublished - Sep 1 2011


  • Cerebral palsy
  • Disability
  • Infant
  • Intellectual
  • Learning disabilities
  • Neonatal mortality
  • Premature

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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