Outcomes of pharmacist-Assisted management ofantiretroviral therapy in patients with HIV infection: A risk-Adjusted analysis

Ofir Noah Nevo, Catherine R. Lesko, Bradford Colwell, Craig Ballard, Stephen R. Cole, W. Christopher Mathews

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose. The impact of pharmacist- assisted management (PAM) of pharmaacotherapy for patients with human immunodeficiency virus (HIV) infection was investigated. Methods. A retrospective cohort analysis was conducted to evaluate antiretroviral therapy (ART) outcomes in treatment-naive patients initiated on ART at an HIV clinic. Elaigible patients enrolled in the clinic during the period 1999-2013 were classified into two groups: those referred to a clinic-based HIV pharmacist for initiation of ART (the PAM group) and those managed by a primary care provider (the control group). The primary study objective was the median time to viral suppression; secondary objectives included the durability of response to the first ART regimen. Relative hazards for the events of interest were estimated using a marginal structural Cox proportional hazards model and Kaplan-Meier curves, with inverse probability weights used to control for selection and confounding bias. Results. Patients referred for PAM services (n = 819) typically had higher baseline viral loads and lower CD4+ cell counts than those in the control group (n = 436). The likelihood of viral suppression during the first two years after ART initiation was significantly higher in the PAM group verasus the control group (hazard ratio, 1.37; 95% confidence interval, 1.18-1.59; p < 0.0001). The median durability of the first ART regimen was 100 months in the PAM group versus 44 months in the control group (p > 0.05). Conclusion. In treatment-naive patients, suppression of HIV viral load occurred earlier when pharmacists assisted with initiating ART than when ART was initiated without that assistance.

Original languageEnglish (US)
Pages (from-to)1463-1470
Number of pages8
JournalAmerican Journal of Health-System Pharmacy
Volume72
Issue number17
DOIs
StatePublished - Sep 1 2015

ASJC Scopus subject areas

  • Pharmacology
  • Health Policy

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