Outcomes of patients with up to 6 years of follow-up from a phase 2 study of idelalisib for relapsed indolent lymphomas

Nina D. Wagner-Johnston, Stephen J. Schuster, Sven deVos, Gilles Salles, Wojciech J. Jurczak, Christopher R. Flowers, Andreas Viardot, Ian W. Flinn, Peter Martin, Guan Xing, Nishanthan Rajakumaraswamy, Ajay K. Gopal

Research output: Contribution to journalArticlepeer-review

Abstract

The phase 2 study of idelalisib monotherapy for indolent non-Hodgkin lymphomas (iNHLs) was completed in 2018; final efficacy and safety data with up to 6.7 years long-term follow-up are reported. Patients with iNHL refractory to both rituximab and an alkylating agent were enrolled and received 150 mg idelalisib twice daily (N = 125). Idelalisib resulted in an overall response rate of 57.6% with 34.4% continuing therapy for ≥12 months. The median progression-free survival and duration of response were 11.0 and 11.8 months for follicular lymphoma, 22.2 and 20.4 months for lymphoplasmacytic lymphoma/Waldenström’s macroglobulinemia (LPL/WM), and 6.6 and 18.4 months for marginal zone lymphoma (MZL). Median overall survival after extended follow-up was 48.6 (95% CI 33.9, 71.7) months. Long-term follow-up did not reveal new safety concerns. These data indicate beneficial outcomes with longer follow-up after idelalisib for treatment of iNHL including in patients with LPL/WM and MZL.

Original languageEnglish (US)
Pages (from-to)1077-1087
Number of pages11
JournalLeukemia and Lymphoma
Volume62
Issue number5
DOIs
StatePublished - 2021

Keywords

  • follicular lymphoma
  • Idelalisib
  • indolent non-Hodgkin lymphoma
  • marginal zone lymphoma
  • PI3K inhibitor
  • Waldenström’s macroglobulinemia

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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