Outcomes of patients with Crohn's disease improved from 1988 to 2008 and were associated with increased specialist care

Geoffrey C. Nguyen, Zoann Nugent, Souradet Shaw, Charles N. Bernstein

Research output: Contribution to journalArticle

Abstract

Background & Aims: We investigated factors that affect long-term outcomes in Crohn's disease (CD). Methods: We performed a retrospective study of 3403 patients with CD, diagnosed between 1988 and 2008 in Manitoba, Canada. Subjects were assigned to cohorts based on diagnosis year: cohort I (before 1996), cohort II (19962000), or cohort III (2001 and after). We compared risks for surgery and hospitalization among the cohorts and assessed use of immunomodulators and specialists. Results: The 5-year risks of first surgery were 30%, 22%, and 18% for cohorts I, II, and III, respectively. The adjusted hazard ratios for first surgery in cohorts II and III, compared with cohort I, were 0.72 (95% confidence interval [CI], 0.620.84) and 0.57 (95% CI, 0.480.68), respectively. The adjusted hazard ratio for cohort III, compared with cohort II, was 0.79 (95% CI, 0.650.97). There was a higher prevalence of visits to a gastroenterologist within the first year of diagnosis among cohorts II and III (cohort I, 53%; cohort II, 72%; and cohort III, 88%; P

Original languageEnglish (US)
Pages (from-to)90-97
Number of pages8
JournalGastroenterology
Volume141
Issue number1
DOIs
StatePublished - Jul 2011

Fingerprint

Crohn Disease
Confidence Intervals
Manitoba
Immunologic Factors
Canada
Hospitalization
Retrospective Studies
Gastroenterologists

Keywords

  • Immunomodulators
  • Inflammatory Bowel Disease
  • Patient Management
  • Treatment Outcome

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Outcomes of patients with Crohn's disease improved from 1988 to 2008 and were associated with increased specialist care. / Nguyen, Geoffrey C.; Nugent, Zoann; Shaw, Souradet; Bernstein, Charles N.

In: Gastroenterology, Vol. 141, No. 1, 07.2011, p. 90-97.

Research output: Contribution to journalArticle

Nguyen, Geoffrey C. ; Nugent, Zoann ; Shaw, Souradet ; Bernstein, Charles N. / Outcomes of patients with Crohn's disease improved from 1988 to 2008 and were associated with increased specialist care. In: Gastroenterology. 2011 ; Vol. 141, No. 1. pp. 90-97.
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