Outcomes of liver transplantation for glycogen storage disease: A matched-control study and a review of literature

Anurag Maheshwari, Rebecca Rankin, Dorry Segev, Paul J. Thuluvath

Research output: Contribution to journalArticle

Abstract

Background: The clinical characteristics and outcomes of patients with glycogen storage disease (GSD) who undergo liver transplantation (LT) have not been well defined. In this study, our objective was to determine the outcome of LT in patients with GSD and compare it with a comparable group of patients without GSD (matched controls). Methods: UNOS data from 1986 to 2007 were used for this study. For each GSD patient (n=95; men 62%) who was transplanted, three patients (n=285, men 60%) without GSD (case controls) matched for age±fiveyr, year of transplantation and donor risk index (DRI)±0.2 were identified from the UNOS database in a random manner. Unadjusted patient survival was determined by Kaplan-Meier survival analysis and significance determined by log-rank test. Results: The mean age of the group was 17.9yr. GSD patients had lower BMI (22 vs. 24, p=0.002), lower serum bilirubin (2.7 vs. 13.5mg/dL, p

Original languageEnglish (US)
Pages (from-to)432-436
Number of pages5
JournalClinical Transplantation
Volume26
Issue number3
DOIs
StatePublished - May 2012

Fingerprint

Glycogen Storage Disease
Liver Glycogen
Liver Transplantation
Kaplan-Meier Estimate
Survival Analysis
Bilirubin
Age Groups
Transplantation
Tissue Donors
Databases
Survival
Serum

Keywords

  • Glycogen storage disease
  • Liver transplantation
  • Outcomes, case control
  • UNOS database

ASJC Scopus subject areas

  • Transplantation

Cite this

Outcomes of liver transplantation for glycogen storage disease : A matched-control study and a review of literature. / Maheshwari, Anurag; Rankin, Rebecca; Segev, Dorry; Thuluvath, Paul J.

In: Clinical Transplantation, Vol. 26, No. 3, 05.2012, p. 432-436.

Research output: Contribution to journalArticle

Maheshwari, Anurag ; Rankin, Rebecca ; Segev, Dorry ; Thuluvath, Paul J. / Outcomes of liver transplantation for glycogen storage disease : A matched-control study and a review of literature. In: Clinical Transplantation. 2012 ; Vol. 26, No. 3. pp. 432-436.
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