Outcomes of Infrainguinal Lower Extremity Bypass Are Superior in Kidney Transplant Recipients Than Patients with Dialysis

Besma Nejim, Caitlin W. Hicks, Isibor Arhuidese, Satinderjit Locham, Hanaa Dakour-Aridi, Mahmoud Malas

Research output: Contribution to journalArticle

Abstract

Patients with end-stage renal disease (ESRD) whether on dialysis therapy (DT) or who received a kidney transplant (KT) have previously shown unfavorable surgical outcomes. Little is known about the comparative efficacy and durability of lower extremity bypass (LEB) in those patients. The Vascular Quality Initiative database was explored to identify DT or KT recipients (2003–2016) who had LEB. We included 1,714 bypass procedures; DT: 1,512 (88.2%). Primary patency (PP) at 2 year was comparable between KT and DT groups (PP [95% confidence interval {CI}]: 77.0% [69.7%–82.8%] vs. 80.5% [77.8%–82.9%]; P = 0.212), and the risk-adjusted hazard was similar (adjusted hazard ratio [aHR] [95% CI]: 0.89 [0.61–1.30]; P = 0.540). Amputation-free survival (AFS) at 2 year was more favorable in KT group (AFS [95% CI]: 73.1% [66.3%–78.8%] vs. 48.0% [45.4%–50.6%]; P < 0.001), (aHR [95% CI]: 2.29 [1.62–3.23]; P < 0.001). Patients on DT exhibited a higher risk of mortality than KT recipients (aHR [95% CI]: 2.94 [2.07–4.17]; P < 0.001). This study demonstrated superior limb outcomes in KT recipients than patients on DT after LEB. Despite the comparable PP, the risk of amputation or death was doubled in patients on DT compared with KT recipients. Because both groups were similar in several baseline characteristics, the difference in outcome is likely driven by the positive effect of KT on the physiological milieu of these patients.

Original languageEnglish (US)
JournalAnnals of Vascular Surgery
DOIs
StateAccepted/In press - Jan 1 2019

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Dialysis
Lower Extremity
Kidney
Confidence Intervals
Amputation
Transplants
Therapeutics
Survival
Transplant Recipients
Group Psychotherapy
Chronic Kidney Failure
Blood Vessels
Extremities
Databases
Mortality

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

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Outcomes of Infrainguinal Lower Extremity Bypass Are Superior in Kidney Transplant Recipients Than Patients with Dialysis. / Nejim, Besma; Hicks, Caitlin W.; Arhuidese, Isibor; Locham, Satinderjit; Dakour-Aridi, Hanaa; Malas, Mahmoud.

In: Annals of Vascular Surgery, 01.01.2019.

Research output: Contribution to journalArticle

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abstract = "Patients with end-stage renal disease (ESRD) whether on dialysis therapy (DT) or who received a kidney transplant (KT) have previously shown unfavorable surgical outcomes. Little is known about the comparative efficacy and durability of lower extremity bypass (LEB) in those patients. The Vascular Quality Initiative database was explored to identify DT or KT recipients (2003–2016) who had LEB. We included 1,714 bypass procedures; DT: 1,512 (88.2{\%}). Primary patency (PP) at 2 year was comparable between KT and DT groups (PP [95{\%} confidence interval {CI}]: 77.0{\%} [69.7{\%}–82.8{\%}] vs. 80.5{\%} [77.8{\%}–82.9{\%}]; P = 0.212), and the risk-adjusted hazard was similar (adjusted hazard ratio [aHR] [95{\%} CI]: 0.89 [0.61–1.30]; P = 0.540). Amputation-free survival (AFS) at 2 year was more favorable in KT group (AFS [95{\%} CI]: 73.1{\%} [66.3{\%}–78.8{\%}] vs. 48.0{\%} [45.4{\%}–50.6{\%}]; P < 0.001), (aHR [95{\%} CI]: 2.29 [1.62–3.23]; P < 0.001). Patients on DT exhibited a higher risk of mortality than KT recipients (aHR [95{\%} CI]: 2.94 [2.07–4.17]; P < 0.001). This study demonstrated superior limb outcomes in KT recipients than patients on DT after LEB. Despite the comparable PP, the risk of amputation or death was doubled in patients on DT compared with KT recipients. Because both groups were similar in several baseline characteristics, the difference in outcome is likely driven by the positive effect of KT on the physiological milieu of these patients.",
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