TY - JOUR
T1 - Outcomes of Boston Keratoprosthesis in Aniridia
T2 - A Retrospective Multicenter Study
AU - Akpek, Esen Karamursel
AU - Harissi-Dagher, Mona
AU - Petrarca, Robert
AU - Butrus, Salim I.
AU - Pineda, Roberto
AU - Aquavella, James V.
AU - Dohlman, Claes H.
N1 - Funding Information:
This study was supported in part by a William and Mary Greve Scholarship (Dr Akpek) from Research to Prevent Blindness, New York, New York and The Director’s Discovery Fund of The Wilmer Eye Institute, Baltimore, Maryland and a Departmental Fund from the Massachusetts Eye and Ear Infirmary, Boston, Massachusetts and the recipient of Alcon Research Institute Award (Dr Dohlman). The authors indicate no financial conflict of interest. All authors were involved in the design and conduct of the study, collection of data, management, analysis, interpretation, and preparation of the article, and preparation, review and approval of the manuscript. The study was reviewed and approved by the Institutional Review Board of each institute involved, in adherence to Declaration of Helsinki. Surgeries were performed at multiple sites by four of the authors (E.K.A., J.V.A., R.P., S.A.B., C.H.D.), using the Boston type I device. The devices were obtained from the Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.
PY - 2007/8
Y1 - 2007/8
N2 - Purpose: To evaluate the long-term outcomes of keratoprosthesis as an alternative surgical procedure in the management of aniridic keratopathy. Design: Retrospective, multicenter case series. Methods: Fifteen adult patients (16 eyes) with aniridia who were deemed at high risk for regular donor corneal transplantation underwent a Boston type I keratoprosthesis procedure for visual rehabilitation. Device retention rate, preoperative and postoperative visual acuity, and intraoperative and postoperative complications were studied. Results: The mean age of the patients was 45 (median 50) years. Six of the patients were females. Eleven patients had previously undergone donor corneal transplantations (average two grafts), with failure. In 10 patients, the keratoprosthesis surgery was combined with other procedures such as cataract extraction, tube shunt implantation, vitrectomy, and intraocular lens removal. No intraoperative complications were encountered. The follow-up ranged from two months to 85 months, with a median of 17 months. All devices remained in situ throughout the entire follow-up period. The visual acuity improved in all but one patient from a median of counting fingers (light perception to 20/300) to 20/200 (hand motions to 20/60). Comorbid preoperative conditions particularly optic nerve and foveal hypoplasia limited the final postoperative vision. No endophthalmitis or extrusion of the device occurred. One device required repair procedure without necessitating a removal. Conclusions: Keratoprosthesis offers significant vision benefits in this patient group.
AB - Purpose: To evaluate the long-term outcomes of keratoprosthesis as an alternative surgical procedure in the management of aniridic keratopathy. Design: Retrospective, multicenter case series. Methods: Fifteen adult patients (16 eyes) with aniridia who were deemed at high risk for regular donor corneal transplantation underwent a Boston type I keratoprosthesis procedure for visual rehabilitation. Device retention rate, preoperative and postoperative visual acuity, and intraoperative and postoperative complications were studied. Results: The mean age of the patients was 45 (median 50) years. Six of the patients were females. Eleven patients had previously undergone donor corneal transplantations (average two grafts), with failure. In 10 patients, the keratoprosthesis surgery was combined with other procedures such as cataract extraction, tube shunt implantation, vitrectomy, and intraocular lens removal. No intraoperative complications were encountered. The follow-up ranged from two months to 85 months, with a median of 17 months. All devices remained in situ throughout the entire follow-up period. The visual acuity improved in all but one patient from a median of counting fingers (light perception to 20/300) to 20/200 (hand motions to 20/60). Comorbid preoperative conditions particularly optic nerve and foveal hypoplasia limited the final postoperative vision. No endophthalmitis or extrusion of the device occurred. One device required repair procedure without necessitating a removal. Conclusions: Keratoprosthesis offers significant vision benefits in this patient group.
UR - http://www.scopus.com/inward/record.url?scp=34447623215&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447623215&partnerID=8YFLogxK
U2 - 10.1016/j.ajo.2007.04.036
DO - 10.1016/j.ajo.2007.04.036
M3 - Article
C2 - 17543875
AN - SCOPUS:34447623215
SN - 0002-9394
VL - 144
SP - 227-231.e1
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 2
ER -