Outcomes attributable to neonatal candidiasis

Theoklis E. Zaoutis, Kateri Heydon, Russell Localio, Thomas J. Walsh, Chris Feudtner

Research output: Contribution to journalArticle

Abstract

Background. The incidence of candidiasis has increased in neonatal intensive care units, and invasive candidiasis is associated with significant morbidity and mortality. However, few data exist on outcomes directly attributable to neonatal candidiasis. Methods. We estimated the incidence of systemic candidiasis in hospitalized neonates within the United States and determined the attributable mortality, length of hospital stay, and associated costs. We used the 2003 Kid's Inpatient Database from the Healthcare Cost and Utilization Project. Systemic candidiasis and comorbidities were defined by International Classification of Diseases, Ninth Revision, Clinical Modification codes. Neonates with uncomplicated births and neonates who died within the first 3 days of life were excluded. We used propensity score methods to balance covariates between the neonates with and neonates without candidiasis. Attributable outcomes were calculated between propensity score-matched neonates with and neonates without candidiasis. Because of the known confounding effect of birth weight, we performed separate propensity score analyses for extremely low birth weight (ELBW) neonates (i.e., neonates weighing

Original languageEnglish (US)
Pages (from-to)1187-1193
Number of pages7
JournalClinical Infectious Diseases
Volume44
Issue number9
DOIs
Publication statusPublished - May 1 2007
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

Cite this

Zaoutis, T. E., Heydon, K., Localio, R., Walsh, T. J., & Feudtner, C. (2007). Outcomes attributable to neonatal candidiasis. Clinical Infectious Diseases, 44(9), 1187-1193. https://doi.org/10.1086/513196