Outcomes among children who received a kidney transplant in the united states from a hepatitis b core antibody-positive donor, 1995-2010

Rebecca L. Ruebner, Taylor Moatz, Sandra Amaral, Peter P. Reese, Emily A. Blumberg, Jodi M. Smith, Lara Danziger-Isakov, Benjamin L. Laskin

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Accepting kidneys for transplant from donors with a history of hepatitis B virus infection may increase the availability of organs for those with end-stage kidney disease. In adult recipients, kidney transplants from hepatitis B virus core antibody-positive donors have resulted in favorable graft and patient survival rates. However, pediatric organ transplant recipients have developing immune systems and a higher risk of infectious complications than adults. Accordingly, little is known about the outcomes of children who have received a kidney transplant from a hepatitis B virus core antibody-positive donor. Methods. We included 11 898 children ≤18 years of age who received a first kidney transplant in the United States between January 1, 1995, and December 31, 2010, and who were recorded in the Scientific Registry of Transplant Recipients.We examined differences in graft and patient survival rates among children who received a kidney transplant from a hepatitis B virus core antibody-positive donor. Results. There were 199 children (1.7%) who received a kidney transplant from a hepatitis B virus core antibody-positive donor.More than 80% of these transplants occurred in recipients who were hepatitis B virus core antibody and surface antigen negative. After a median follow-up of 7.9 years, there were no significant differences in the adjusted graft (hazard ratio [HR], 1.03 [95% confidence interval (CI), 0.80-1.31]) or patient (HR, 1.12 [95% CI, 0.73-1.73]) survival rates according to donor core antibody status. Conclusions. It may be acceptable, on a case-by-case basis, to consider hepatitis B virus core antibody-positive donors for kidney transplants to seroprotected children with end-stage kidney disease.

Original languageEnglish (US)
Pages (from-to)439-445
Number of pages7
JournalJournal of the Pediatric Infectious Diseases Society
Volume5
Issue number4
DOIs
StatePublished - Dec 2016
Externally publishedYes

Keywords

  • Children
  • Hepatitis B
  • Kidney transplant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Outcomes among children who received a kidney transplant in the united states from a hepatitis b core antibody-positive donor, 1995-2010'. Together they form a unique fingerprint.

Cite this