Outcome of screening endoscopy in common variable immunodeficiency disorder and X-linked agammaglobulinemia

L. J. Maarschalk-Ellerbroek, B. Oldenburg, I. M H Mombers, A. I M Hoepelman, L. A A Brosens, G. J A Offerhaus, P. M. Ellerbroek

Research output: Contribution to journalArticlepeer-review

Abstract

Gastrointestinal symptoms are common in patients with common variable immunodeficiency disorders (CVID) and less frequent in X-linked agammaglobulinemia (XLA) although the exact prevalence is not well established. In this study, endoscopic screening was performed in 30 patients with CVID and four patients with XLA. Endoscopic and/or histological abnormalities were detected in 25 of 30 patients with CVID (83 %), regardless of symptoms, and in nine of these patients the results prompted medical treatment. Helicobacter pylori-associated gastritis, adenomatous polyps, and lymphoid hyperplasia were most frequently encountered; no malignancies were detected. Adenomatous polyps were found in two of the four patients with XLA at a relative young age. In conclusion, gastrointestinal pathology is frequent in patients with CVID regardless of symptoms. Patients with XLA seem to be at risk for colorectal adenomas at a young age.

Original languageEnglish (US)
Pages (from-to)320-323
Number of pages4
JournalEndoscopy
Volume45
Issue number4
DOIs
StatePublished - 2013
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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