Outcome of delirium in critically ill patients: Systematic review and meta-analysis

Jorge I F Salluh, Han Wang, Eric B. Schneider, Neeraja Nagaraja, Gayane Yenokyan, Abdulla Damluji, Rodrigo B. Serafim, Robert D. Stevens

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To determine the relation between delirium in critically ill patients and their outcomes in the short term (in the intensive care unit and in hospital) and after discharge from hospital. DESIGN: Systematic review and meta-analysis of published studies. DATA SOURCES: PubMed, Embase, CINAHL, Cochrane Library, and PsychINFO, with no language restrictions, up to 1 January 2015. ELIGIBILITY CRITERIA FOR SELECTION STUDIES: Reports were eligible for inclusion if they were prospective observational cohorts or clinical trials of adults in intensive care units who were assessed with a validated delirium screening or rating system, and if the association was measured between delirium and at least one of four clinical endpoints (death during admission, length of stay, duration of mechanical ventilation, and any outcome after hospital discharge). Studies were excluded if they primarily enrolled patients with a neurological disorder or patients admitted to intensive care after cardiac surgery or organ/tissue transplantation, or centered on sedation management or alcohol or substance withdrawal. Data were extracted on characteristics of studies, populations sampled, identification of delirium, and outcomes. Random effects models and metaregression analyses were used to pool data from individual studies. RESULTS: Delirium was identified in 5280 of 16 595 (31.8%) critically ill patients reported in 42 studies. When compared with control patients without delirium, patients with delirium had significantly higher mortality during admission (risk ratio 2.19, 94% confidence interval 1.78 to 2.70; P

Original languageEnglish (US)
Article numberh2538
Pages (from-to)1-10
Number of pages10
JournalBMJ (Online)
Volume350
DOIs
StatePublished - Jun 3 2015

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Delirium
Critical Illness
Meta-Analysis
Intensive Care Units
Tissue Transplantation
Organ Transplantation
Population Characteristics
Critical Care
Nervous System Diseases
Artificial Respiration
PubMed
Patient Selection
Thoracic Surgery
Libraries
Length of Stay
Language
Odds Ratio
Alcohols
Clinical Trials
Confidence Intervals

ASJC Scopus subject areas

  • Medicine(all)

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Outcome of delirium in critically ill patients : Systematic review and meta-analysis. / Salluh, Jorge I F; Wang, Han; Schneider, Eric B.; Nagaraja, Neeraja; Yenokyan, Gayane; Damluji, Abdulla; Serafim, Rodrigo B.; Stevens, Robert D.

In: BMJ (Online), Vol. 350, h2538, 03.06.2015, p. 1-10.

Research output: Contribution to journalArticle

Salluh, Jorge I F ; Wang, Han ; Schneider, Eric B. ; Nagaraja, Neeraja ; Yenokyan, Gayane ; Damluji, Abdulla ; Serafim, Rodrigo B. ; Stevens, Robert D. / Outcome of delirium in critically ill patients : Systematic review and meta-analysis. In: BMJ (Online). 2015 ; Vol. 350. pp. 1-10.
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