TY - JOUR
T1 - Outcome Measures for Evaluation of Treatments for Osteonecrosis
AU - Jones, Lynne C.
AU - Hungerford, Marc W.
AU - Khanuja, Harpal S.
AU - Hungerford, David S.
PY - 2009/4
Y1 - 2009/4
N2 - With the advent of cell-based therapies, biologics, and pharmaceuticals for the potential treatment of osteonecrosis, it is important to conduct evaluations using scientifically accepted outcomes measures. For the treatment of osteonecrosis, most studies have focused on pain relief, surgery, or the need for surgery, disease progression (advancing stage), and change in lesion size. Quantification of imaging techniques continue to gain in sophistication but have not yet been validated for use in clinical trials. Despite recent interest in using biomarkers or genetic markers in the diagnosis and analysis of disease progression, more research is needed to determine the sensitivity and specificity of these techniques with respect to osteonecrosis.
AB - With the advent of cell-based therapies, biologics, and pharmaceuticals for the potential treatment of osteonecrosis, it is important to conduct evaluations using scientifically accepted outcomes measures. For the treatment of osteonecrosis, most studies have focused on pain relief, surgery, or the need for surgery, disease progression (advancing stage), and change in lesion size. Quantification of imaging techniques continue to gain in sophistication but have not yet been validated for use in clinical trials. Despite recent interest in using biomarkers or genetic markers in the diagnosis and analysis of disease progression, more research is needed to determine the sensitivity and specificity of these techniques with respect to osteonecrosis.
KW - Function assessment
KW - Pain measurement
KW - Quality-of-life measures
KW - Radiographic progression
KW - Treatment outcome
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U2 - 10.1016/j.ocl.2008.10.005
DO - 10.1016/j.ocl.2008.10.005
M3 - Review article
C2 - 19358904
AN - SCOPUS:63549120457
SN - 0030-5898
VL - 40
SP - 179
EP - 191
JO - Orthopedic Clinics of North America
JF - Orthopedic Clinics of North America
IS - 2
ER -