Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003

Katharine Patrick; Rachel Wade; Nick Goulden; Chris Mitchell; Anthony V. Moorman; Clare Rowntree; Sarah Jenkinson; Rachael Hough; Ajay Vora

doi:10.1111/bjh.12882

Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003

Katharine Patrick, Rachel Wade, Nick Goulden, Chris Mitchell, Anthony V. Moorman, Clare Rowntree, Sarah Jenkinson, Rachael Hough, Ajay Vora

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

Summary: We investigated the outcome for children and young people with Early T-precursor acute lymphoblastic leukaemia (ETP-ALL), a recently described poor prognosis sub-group of T-ALL, treated on a contemporary protocol, UKALL 2003. After a median follow-up of 4 years and 10 months, the ETP sub-group, representing 16% of T-ALL patients, had non-significantly inferior 5-year event-free survival (76·7% vs. 84·6%, P = 0·2) and overall survival (82·4% vs. 90·9%, P = 0·1), and a higher relapse rate (18·6% vs. 9·6%, P = 0·1) compared to typical T-ALL. ETP-ALL has an intermediate risk outcome, which does not warrant experimental treatment or first remission allogeneic transplant for the group universally.

Original language	English (US)
Pages (from-to)	421-424
Number of pages	4
Journal	British journal of haematology
Volume	166
Issue number	3
DOIs	https://doi.org/10.1111/bjh.12882
State	Published - Aug 2014
Externally published	Yes

Keywords

Acute lymphoblastic leukaemia
Child
Early T-precursor

ASJC Scopus subject areas

Hematology

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10.1111/bjh.12882

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title = "Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003",

abstract = "Summary: We investigated the outcome for children and young people with Early T-precursor acute lymphoblastic leukaemia (ETP-ALL), a recently described poor prognosis sub-group of T-ALL, treated on a contemporary protocol, UKALL 2003. After a median follow-up of 4 years and 10 months, the ETP sub-group, representing 16% of T-ALL patients, had non-significantly inferior 5-year event-free survival (76·7% vs. 84·6%, P = 0·2) and overall survival (82·4% vs. 90·9%, P = 0·1), and a higher relapse rate (18·6% vs. 9·6%, P = 0·1) compared to typical T-ALL. ETP-ALL has an intermediate risk outcome, which does not warrant experimental treatment or first remission allogeneic transplant for the group universally.",

keywords = "Acute lymphoblastic leukaemia, Child, Early T-precursor",

author = "Katharine Patrick and Rachel Wade and Nick Goulden and Chris Mitchell and Moorman, {Anthony V.} and Clare Rowntree and Sarah Jenkinson and Rachael Hough and Ajay Vora",

year = "2014",

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doi = "10.1111/bjh.12882",

language = "English (US)",

volume = "166",

pages = "421--424",

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AU - Patrick, Katharine

AU - Wade, Rachel

AU - Goulden, Nick

AU - Mitchell, Chris

AU - Moorman, Anthony V.

AU - Rowntree, Clare

AU - Jenkinson, Sarah

AU - Hough, Rachael

AU - Vora, Ajay

PY - 2014/8

Y1 - 2014/8

N2 - Summary: We investigated the outcome for children and young people with Early T-precursor acute lymphoblastic leukaemia (ETP-ALL), a recently described poor prognosis sub-group of T-ALL, treated on a contemporary protocol, UKALL 2003. After a median follow-up of 4 years and 10 months, the ETP sub-group, representing 16% of T-ALL patients, had non-significantly inferior 5-year event-free survival (76·7% vs. 84·6%, P = 0·2) and overall survival (82·4% vs. 90·9%, P = 0·1), and a higher relapse rate (18·6% vs. 9·6%, P = 0·1) compared to typical T-ALL. ETP-ALL has an intermediate risk outcome, which does not warrant experimental treatment or first remission allogeneic transplant for the group universally.

AB - Summary: We investigated the outcome for children and young people with Early T-precursor acute lymphoblastic leukaemia (ETP-ALL), a recently described poor prognosis sub-group of T-ALL, treated on a contemporary protocol, UKALL 2003. After a median follow-up of 4 years and 10 months, the ETP sub-group, representing 16% of T-ALL patients, had non-significantly inferior 5-year event-free survival (76·7% vs. 84·6%, P = 0·2) and overall survival (82·4% vs. 90·9%, P = 0·1), and a higher relapse rate (18·6% vs. 9·6%, P = 0·1) compared to typical T-ALL. ETP-ALL has an intermediate risk outcome, which does not warrant experimental treatment or first remission allogeneic transplant for the group universally.

KW - Acute lymphoblastic leukaemia

KW - Child

KW - Early T-precursor

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Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003

Abstract

Keywords

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