Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003

Katharine Patrick, Rachel Wade, Nick Goulden, Chris Mitchell, Anthony V. Moorman, Clare Rowntree, Sarah Jenkinson, Rachael Hough, Ajay Vora

Research output: Contribution to journalArticlepeer-review

Abstract

Summary: We investigated the outcome for children and young people with Early T-precursor acute lymphoblastic leukaemia (ETP-ALL), a recently described poor prognosis sub-group of T-ALL, treated on a contemporary protocol, UKALL 2003. After a median follow-up of 4 years and 10 months, the ETP sub-group, representing 16% of T-ALL patients, had non-significantly inferior 5-year event-free survival (76·7% vs. 84·6%, P = 0·2) and overall survival (82·4% vs. 90·9%, P = 0·1), and a higher relapse rate (18·6% vs. 9·6%, P = 0·1) compared to typical T-ALL. ETP-ALL has an intermediate risk outcome, which does not warrant experimental treatment or first remission allogeneic transplant for the group universally.

Original languageEnglish (US)
Pages (from-to)421-424
Number of pages4
JournalBritish journal of haematology
Volume166
Issue number3
DOIs
StatePublished - Aug 2014
Externally publishedYes

Keywords

  • Acute lymphoblastic leukaemia
  • Child
  • Early T-precursor

ASJC Scopus subject areas

  • Hematology

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