Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003

Katharine Patrick, Rachel Wade, Nick Goulden, Chris Mitchell, Anthony Moorman, Clare Rowntree, Sarah Jenkinson, Rachael Hough, Ajay Vora

Research output: Contribution to journalArticle

Abstract

Summary: We investigated the outcome for children and young people with Early T-precursor acute lymphoblastic leukaemia (ETP-ALL), a recently described poor prognosis sub-group of T-ALL, treated on a contemporary protocol, UKALL 2003. After a median follow-up of 4 years and 10 months, the ETP sub-group, representing 16% of T-ALL patients, had non-significantly inferior 5-year event-free survival (76·7% vs. 84·6%, P = 0·2) and overall survival (82·4% vs. 90·9%, P = 0·1), and a higher relapse rate (18·6% vs. 9·6%, P = 0·1) compared to typical T-ALL. ETP-ALL has an intermediate risk outcome, which does not warrant experimental treatment or first remission allogeneic transplant for the group universally.

Original languageEnglish (US)
Pages (from-to)421-424
Number of pages4
JournalBritish Journal of Haematology
Volume166
Issue number3
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

T-Lymphoid Precursor Cells
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Disease-Free Survival
Transplants
Recurrence
Survival
Therapeutics

Keywords

  • Acute lymphoblastic leukaemia
  • Child
  • Early T-precursor

ASJC Scopus subject areas

  • Hematology

Cite this

Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003. / Patrick, Katharine; Wade, Rachel; Goulden, Nick; Mitchell, Chris; Moorman, Anthony; Rowntree, Clare; Jenkinson, Sarah; Hough, Rachael; Vora, Ajay.

In: British Journal of Haematology, Vol. 166, No. 3, 01.01.2014, p. 421-424.

Research output: Contribution to journalArticle

Patrick, Katharine ; Wade, Rachel ; Goulden, Nick ; Mitchell, Chris ; Moorman, Anthony ; Rowntree, Clare ; Jenkinson, Sarah ; Hough, Rachael ; Vora, Ajay. / Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003. In: British Journal of Haematology. 2014 ; Vol. 166, No. 3. pp. 421-424.
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