TY - JOUR
T1 - Outcome and Prognostic Factors of Phacoemulsification Cataract Surgery in Vogt-Koyanagi-Harada Uveitis
AU - Ji, Yan
AU - Hu, Ke
AU - Li, Can
AU - Li, Pinghua
AU - Kijlstra, Aize
AU - Eghrari, Allen Omid
AU - Lei, Bo
AU - Du, Liping
AU - Wan, Wenjuan
AU - Yang, Peizeng
N1 - Funding Information:
Funding/Support: This work was supported by Natural Science Foundation Project ( 81570832 ), Chongqing Key Laboratory of Ophthalmology (CSTC, 2008CA5003 , Chongqing, China), National Key Clinical Specialties Construction Program of China , Key Project of Health Bureau of Chongqing (2012-1-003), Chongqing Science & Technology Platform and Base Construction Program ( cstc2014pt-sy10002 , Chongqing, China), Natural Science Foundation Project of Chongqing ( cstc2017shmsA130073 , Chongqing, China), Chongqing Science and Technology Commission ( cstc2018jcyjA0429 , Chongqing, China) and High Level Youth Meidical Researchs’ Foundation of Chongqing Science and Technology Commission Combined with Health and Family Planning Commision (2018GDRC008, Chongqing, China). Financial Disclosures: The following authors have no financial disclosures: Yan Ji, Ke Hu, Can Li, Pinghua Li, Aize Kijlstra, Allen Omid Eghrari, Bo Lei, Liping Du, Wenjuan Wan, and Peizeng Yang. All authors attest that they meet the current ICMJE criteria for authorship.
Publisher Copyright:
© 2018 Elsevier Inc.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/12
Y1 - 2018/12
N2 - Purpose: To investigate visual outcome and prognostic factors following cataract surgery in patients with Vogt-Koyanagi-Harada (VKH) disease. Design: Retrospective, interventional case series. Methods: The history, clinical characteristics, best-corrected visual acuity (BCVA), full-field electroretinogram (ERG), intraocular inflammation, complications, and extraocular manifestations were analyzed retrospectively. Results: One hundred and forty-eight male (214 eyes) and 138 female (194 eyes) VKH patients with complicated cataract were included. Surgery was performed on 352 eyes after complete control of intraocular inflammation for at least 3 months. In another set of 56 eyes, surgery was done 1 month after intraocular inflammation control. There was no difference in postoperative complications or BCVA between these 2 groups. The main complications after surgery were hyphema, ocular hypertension, and moderate anterior chamber reaction. Average preoperative visual acuity was 0.08. At last visit, BCVA was improved in 405 eyes (99.3%). The preoperative BCVA, treatment delay after disease onset, preoperative intraocular hypertension, and iris synechiae were associated with final visual outcome. Other parameters such as postoperative inflammation, IOL type, and presence of extraocular VKH features did not affect final BCVA. Poor visual acuity was caused by optic nerve atrophy, choroidoretinal neovascularization, and subretinal fibrosis. Poor postoperative BCVA was associated with an abnormal preoperative ERG profile. Conclusions: Phacoemulsification and IOL implantation in VKH patients can be safely and successfully performed in quiet eyes even after 1 month following the last signs of inflammation. Visual prognosis was associated with preoperative BCVA, treatment delay after disease onset, preoperative intraocular hypertension, iris synechiae, and presence of preoperative ERG abnormalities.
AB - Purpose: To investigate visual outcome and prognostic factors following cataract surgery in patients with Vogt-Koyanagi-Harada (VKH) disease. Design: Retrospective, interventional case series. Methods: The history, clinical characteristics, best-corrected visual acuity (BCVA), full-field electroretinogram (ERG), intraocular inflammation, complications, and extraocular manifestations were analyzed retrospectively. Results: One hundred and forty-eight male (214 eyes) and 138 female (194 eyes) VKH patients with complicated cataract were included. Surgery was performed on 352 eyes after complete control of intraocular inflammation for at least 3 months. In another set of 56 eyes, surgery was done 1 month after intraocular inflammation control. There was no difference in postoperative complications or BCVA between these 2 groups. The main complications after surgery were hyphema, ocular hypertension, and moderate anterior chamber reaction. Average preoperative visual acuity was 0.08. At last visit, BCVA was improved in 405 eyes (99.3%). The preoperative BCVA, treatment delay after disease onset, preoperative intraocular hypertension, and iris synechiae were associated with final visual outcome. Other parameters such as postoperative inflammation, IOL type, and presence of extraocular VKH features did not affect final BCVA. Poor visual acuity was caused by optic nerve atrophy, choroidoretinal neovascularization, and subretinal fibrosis. Poor postoperative BCVA was associated with an abnormal preoperative ERG profile. Conclusions: Phacoemulsification and IOL implantation in VKH patients can be safely and successfully performed in quiet eyes even after 1 month following the last signs of inflammation. Visual prognosis was associated with preoperative BCVA, treatment delay after disease onset, preoperative intraocular hypertension, iris synechiae, and presence of preoperative ERG abnormalities.
UR - http://www.scopus.com/inward/record.url?scp=85054432919&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054432919&partnerID=8YFLogxK
U2 - 10.1016/j.ajo.2018.08.041
DO - 10.1016/j.ajo.2018.08.041
M3 - Article
C2 - 30194930
AN - SCOPUS:85054432919
SN - 0002-9394
VL - 196
SP - 121
EP - 128
JO - American journal of ophthalmology
JF - American journal of ophthalmology
ER -