Outcome after cytoreductive nephrectomy for metastatic renal cell carcinoma is predicted by fractional percentage of tumour volume removed

Phillip Martin Pierorazio, James M. McKiernan, Tara R. McCann, Supriya Mohile, Daniel Petrylak, Mitchell C. Benson

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To determine if the fractional percentage of tumour volume (FPTV) removed at cytoreductive nephrectomy predicts disease-specific survival (DSS), as metastatic renal cell carcinoma ((M+)RCC) is associated with poor overall survival with only a 10-20% patient survival at 2 years. PATIENTS AND METHODS: The Columbia Urologic Oncology Database was reviewed; 1016 patients had renal surgery from 1988 to 2005, 78 patients with (M+)RCC underwent nephrectomy. The FPTV removed was determined using pathological and imaging reports. The patients were stratified as having a > or 90% FPTV. The median DSS times were 11.6 and 2.9 months for patients with >90% and 90% FPTV in a univariate model (P = 0.016) and 0.29 in multivariate analysis (P = 0.02). Patients with a

Original languageEnglish (US)
Pages (from-to)755-759
Number of pages5
JournalBJU International
Volume100
Issue number4
DOIs
StatePublished - Oct 2007
Externally publishedYes

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Tumor Burden
Nephrectomy
Renal Cell Carcinoma
Survival
Multivariate Analysis
Databases
Kidney

Keywords

  • Cytoreductive
  • Kidney neoplasm
  • Neoplasm metastasis
  • Outcomes
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Urology

Cite this

Outcome after cytoreductive nephrectomy for metastatic renal cell carcinoma is predicted by fractional percentage of tumour volume removed. / Pierorazio, Phillip Martin; McKiernan, James M.; McCann, Tara R.; Mohile, Supriya; Petrylak, Daniel; Benson, Mitchell C.

In: BJU International, Vol. 100, No. 4, 10.2007, p. 755-759.

Research output: Contribution to journalArticle

Pierorazio, Phillip Martin ; McKiernan, James M. ; McCann, Tara R. ; Mohile, Supriya ; Petrylak, Daniel ; Benson, Mitchell C. / Outcome after cytoreductive nephrectomy for metastatic renal cell carcinoma is predicted by fractional percentage of tumour volume removed. In: BJU International. 2007 ; Vol. 100, No. 4. pp. 755-759.
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AU - Petrylak, Daniel

AU - Benson, Mitchell C.

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