Outbreak of influenza A (H3N2) variant virus infection among attendees of an agricultural fair, Pennsylvania, USA, 2011

Karen K. Wong, Adena Greenbaum, Maria E. Moll, James Lando, Erin L. Moore, Rahul Ganatra, Matthew Biggerstaff, Eugene Lam, Erica E. Smith, Aaron D. Storms, Jeffrey R. Miller, Virginia Dato, Kumar Nalluswami, Atmaram Nambiar, Sharon A. Silvestri, James R. Lute, Stephen Ostroff, Kathy Hancock, Alicia Branch, Susan C. TrockAlexander Klimov, Bo Shu, Lynnette Brammer, Scott Epperson, Lyn Finelli, Michael A. Jhung

Research output: Contribution to journalArticle

Abstract

During August 2011, influenza A (H3N2) variant [A(H3N2)v] virus infection developed in a child who attended an agricultural fair in Pennsylvania, USA; the virus resulted from reassortment of a swine influenza virus with influenza A(H1N1)pdm09. We interviewed fair attendees and conducted a retrospective cohort study among members of an agricultural club who attended the fair. Probable and confi rmed cases of A(H3N2)v virus infection were defi ned by serology and genomic sequencing results, respectively. We identifi ed 82 suspected, 4 probable, and 3 confi rmed case-patients who attended the fair. Among 127 cohort study members, the risk for suspected case status increased as swine exposure increased from none (4%; referent) to visiting swine exhibits (8%; relative risk 2.1; 95% CI 0.2-53.4) to touching swine (16%; relative risk 4.4; 95% CI 0.8-116.3). Fairs may be venues for zoonotic transmission of viruses with epidemic potential; thus, health offi cials should investigate respiratory illness outbreaks associated with agricultural events.

Original languageEnglish (US)
Pages (from-to)1937-1944
Number of pages8
JournalEmerging infectious diseases
Volume18
Issue number12
DOIs
StatePublished - Dec 1 2012
Externally publishedYes

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H3N2 Subtype Influenza A Virus
Virus Diseases
Human Influenza
Disease Outbreaks
Swine
Cohort Studies
Viruses
Zoonoses
Serology
Orthomyxoviridae
Retrospective Studies
Health

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Outbreak of influenza A (H3N2) variant virus infection among attendees of an agricultural fair, Pennsylvania, USA, 2011. / Wong, Karen K.; Greenbaum, Adena; Moll, Maria E.; Lando, James; Moore, Erin L.; Ganatra, Rahul; Biggerstaff, Matthew; Lam, Eugene; Smith, Erica E.; Storms, Aaron D.; Miller, Jeffrey R.; Dato, Virginia; Nalluswami, Kumar; Nambiar, Atmaram; Silvestri, Sharon A.; Lute, James R.; Ostroff, Stephen; Hancock, Kathy; Branch, Alicia; Trock, Susan C.; Klimov, Alexander; Shu, Bo; Brammer, Lynnette; Epperson, Scott; Finelli, Lyn; Jhung, Michael A.

In: Emerging infectious diseases, Vol. 18, No. 12, 01.12.2012, p. 1937-1944.

Research output: Contribution to journalArticle

Wong, KK, Greenbaum, A, Moll, ME, Lando, J, Moore, EL, Ganatra, R, Biggerstaff, M, Lam, E, Smith, EE, Storms, AD, Miller, JR, Dato, V, Nalluswami, K, Nambiar, A, Silvestri, SA, Lute, JR, Ostroff, S, Hancock, K, Branch, A, Trock, SC, Klimov, A, Shu, B, Brammer, L, Epperson, S, Finelli, L & Jhung, MA 2012, 'Outbreak of influenza A (H3N2) variant virus infection among attendees of an agricultural fair, Pennsylvania, USA, 2011', Emerging infectious diseases, vol. 18, no. 12, pp. 1937-1944. https://doi.org/10.3201/eid1812.121097
Wong, Karen K. ; Greenbaum, Adena ; Moll, Maria E. ; Lando, James ; Moore, Erin L. ; Ganatra, Rahul ; Biggerstaff, Matthew ; Lam, Eugene ; Smith, Erica E. ; Storms, Aaron D. ; Miller, Jeffrey R. ; Dato, Virginia ; Nalluswami, Kumar ; Nambiar, Atmaram ; Silvestri, Sharon A. ; Lute, James R. ; Ostroff, Stephen ; Hancock, Kathy ; Branch, Alicia ; Trock, Susan C. ; Klimov, Alexander ; Shu, Bo ; Brammer, Lynnette ; Epperson, Scott ; Finelli, Lyn ; Jhung, Michael A. / Outbreak of influenza A (H3N2) variant virus infection among attendees of an agricultural fair, Pennsylvania, USA, 2011. In: Emerging infectious diseases. 2012 ; Vol. 18, No. 12. pp. 1937-1944.
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AU - Klimov, Alexander

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