Outbreak of human parainfluenza virus 3 infections in a hematopoietic stem cell transplant population

K. J. Cortez, D. D. Erdman, T. C.T. Peret, V. J. Gill, R. Childs, A. J. Barrett, J. E. Bennett

Research output: Contribution to journalArticlepeer-review

Abstract

Clinical manifestations and epidemiological features are described for a cluster of 12 cases of human parainfluenza virus 3 (HPIV3) infection that occurred among 64 allogeneic hematopoietic stem cell transplant (SCT) recipients in an 11-week period during spring 2000. Upper respiratory symptoms predominated. Pneumonia occurred in 3 patients and was a contributing factor in the death of 1 patient. Exposure histories and molecular analysis of HPIV3 isolates suggested that both community acquired and nosocomially transmitted infections occurred during this outbreak. A chain of transmission within the outpatient clinic appeared to have occurred in 4 outpatients and to have extended to 2 hospitalized patients. Molecular epidemiology was useful in discerning routes of transmission in this outbreak.

Original languageEnglish (US)
Pages (from-to)1093-1097
Number of pages5
JournalJournal of Infectious Diseases
Volume184
Issue number9
DOIs
StatePublished - Nov 1 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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