OUTBREAK OF COXSACKIE A1 GASTROENTERITIS: A COMPLICATION OF BONE-MARROW TRANSPLANTATION

Timothy R. Townsend, Robert H. Yolken, Catherine A. Bishop, George W. Santos, Elizabeth A. Bolyard, William E. Beschorner, William H. Burns, Rein Saral

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Abstract

In a three-week period 7 of 14 transplant recipients were infected with coxsackie Al virus. Diarrhoea and mortality were significantly associated with infection (7 of 7 infected compared with 0 of 7 non-infected, and 6 of 7 infected compared with 1 of 7 non-infected, respectively). Early in the outbreak, the diarrhoea was presumed to be due to acute graft-versus-host disease (AGVHD). However, the distribution of AGVHD among infected and non-infected patients was nearly equal, and at necropsy 3 of 6 infected patients who had had diarrhoea showed no evidence of gastrointestinal involvement with AGVHD. Infection with viral enteric pathogens may be an important factor in the clinical course of transplant recipients.

Original languageEnglish (US)
Pages (from-to)820-823
Number of pages4
JournalThe Lancet
Volume319
Issue number8276
DOIs
StatePublished - Apr 10 1982

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Townsend, T. R., Yolken, R. H., Bishop, C. A., Santos, G. W., Bolyard, E. A., Beschorner, W. E., Burns, W. H., & Saral, R. (1982). OUTBREAK OF COXSACKIE A1 GASTROENTERITIS: A COMPLICATION OF BONE-MARROW TRANSPLANTATION. The Lancet, 319(8276), 820-823. https://doi.org/10.1016/S0140-6736(82)91872-4