Otologic and leptomeningeal involvements as presenting features in seronegative Wegener granulomatosis

Nadir Yildirim, Atilla Arslanoglu, Nafi Aygun

Research output: Contribution to journalArticlepeer-review

Abstract

Wegener granulomatosis is an immune-mediated, systemic vasculitis with unknown etiology that can be seen in almost any anatomical site. Positivity for antineutrophil cytoplasmic antigene, which is a serological marker, and presence of granulomatous vasculitis in histopathologic specimens from the lesions are accepted as diagnostic. A case of Wegener granulomatosis whose presenting symptoms and signs are related to otologic and meningeal involvement of the disease is reported. Apart from atypical presentation, histopathological and serological findings from this patient remained negative throughout the course of the disease, and the diagnosis was made on the basis of clinical and secondary laboratory findings. We herewith discuss this unusual case in the light of relevant literature.

Original languageEnglish (US)
Pages (from-to)147-149
Number of pages3
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume29
Issue number2
DOIs
StatePublished - Mar 2008

ASJC Scopus subject areas

  • Otorhinolaryngology

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