TY - JOUR
T1 - OtolaryngologyHead and Neck Surgery
AU - Niparko, John K.
AU - Johns, Michael E.
PY - 1995/6/7
Y1 - 1995/6/7
N2 - The recent otolaryngology literature documents advances in understanding several disorders of interest to all physicians. Approaches to head and neck cancer, vocal cord palsy, sinusitis, otitis media, and hearing impairment have been heavily scrutinized in recent publications. A survey of this literature reflects continued progress in further refining interventions and their indications and in assessing patient outcomes for these prevalent disorders. Our molecular understanding of head and neck cancer continues to evolve and promises new directions in treating these lesions. Surgical oncologists have traditionally relied on light microscopic assessment of margins to ensure complete excision of a carcinoma. However, rare cancer cells at the margins of resection or in cervical lymph nodes may escape detection. With the use of molecular techniques, 13 of 25 patients with head and neck squamous cell carcinoma were found to have neoplastic cells in at least one tumor margin deemed to be negative by light.
AB - The recent otolaryngology literature documents advances in understanding several disorders of interest to all physicians. Approaches to head and neck cancer, vocal cord palsy, sinusitis, otitis media, and hearing impairment have been heavily scrutinized in recent publications. A survey of this literature reflects continued progress in further refining interventions and their indications and in assessing patient outcomes for these prevalent disorders. Our molecular understanding of head and neck cancer continues to evolve and promises new directions in treating these lesions. Surgical oncologists have traditionally relied on light microscopic assessment of margins to ensure complete excision of a carcinoma. However, rare cancer cells at the margins of resection or in cervical lymph nodes may escape detection. With the use of molecular techniques, 13 of 25 patients with head and neck squamous cell carcinoma were found to have neoplastic cells in at least one tumor margin deemed to be negative by light.
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U2 - 10.1001/jama.1995.03520450075039
DO - 10.1001/jama.1995.03520450075039
M3 - Article
C2 - 7752428
AN - SCOPUS:0029071745
SN - 0098-7484
VL - 273
SP - 1705
EP - 1706
JO - Journal of the American Medical Association
JF - Journal of the American Medical Association
IS - 21
ER -