@article{e09a952ef0b64b9badea67f1e96efd70,
title = "Otolaryngology Aspects of Chronic Cough",
abstract = "Cough is an increasingly important public health concern, and diagnosis and treatment can be challenging in these complex patients. The purpose of this review is to address the roles of otolaryngology in understanding pathophysiology, and unique aspects in their diagnosis and management. Evidence-based best practice through clinical practice guidelines for cough is emphasized. A step-wise description of the interrelated pathophysiology is used to gain a deeper understanding of contributing disease states and the importance of synergistic effects on cough. Unique perspectives exist from an otolaryngology perspective regarding chronic cough. Included here are the premier role of the larynx, immunity, and the microbiome in the Unified Airway, the interconnected nature of reflux disease with respiratory physiology, a spectrum of neurologic diseases tying aspiration to cough, and maladaptive neuro-based behaviors. Otolaryngology aspects of chronic cough encompass the composite nature of the disease with all of its contributions.",
keywords = "Allergy, Cough, Esophageal reflux, Larynx, Otolaryngology, Respiratory disease, Unified Airway",
author = "Altman, {Kenneth W.} and Lane, {Andrew P.} and Irwin, {Richard S.}",
note = "Funding Information: Conflicts of interest: K. W. Altman has been on the CHEST Organization's Expert Cough Panel since 2013; is presently on the American Laryngological Association's executive council since 2009, and was president in 2017; has received consulting income from Bayer, Kay/Pentax, and 5am Ventures in 2016; in the last 3 years has received speaker honoraria from the Oregon Association of Otolaryngology, Texas Chapter of the American Association of Clinical Endocrinologists, University of Dublin Ireland, and University of Texas Southwestern; and performed expert witness consulting. A. P. Lane has no potential conflicts of interest related to this article; in the past 3 years, has received research funding as the site Principal Investigator for clinical trials from Intersect ENT and Knopp Biosciences; and has done medicolegal expert witness consulting. R. S. Irwin has been the Chair of the CHEST Organization's Expert Cough Panel since 1998, which has developed and published the CHEST Cough Guidelines that are mentioned in this article; he, as codeveloper of the Cough Quality of Life Questionnaire (CQLQ), has received $ 815 in the past 3 years from grant-funded investigators who used the CQLQ as an outcome measure in their study, outside of this work. Conflicts of interest: K. W. Altman has been on the CHEST Organization's Expert Cough Panel since 2013; is presently on the American Laryngological Association's executive council since 2009, and was president in 2017; has received consulting income from Bayer, Kay/Pentax, and 5am Ventures in 2016; in the last 3 years has received speaker honoraria from the Oregon Association of Otolaryngology, Texas Chapter of the American Association of Clinical Endocrinologists, University of Dublin Ireland, and University of Texas Southwestern; and performed expert witness consulting. A. P. Lane has no potential conflicts of interest related to this article; in the past 3 years, has received research funding as the site Principal Investigator for clinical trials from Intersect ENT and Knopp Biosciences; and has done medicolegal expert witness consulting. R. S. Irwin has been the Chair of the CHEST Organization's Expert Cough Panel since 1998, which has developed and published the CHEST Cough Guidelines that are mentioned in this article; he, as codeveloper of the Cough Quality of Life Questionnaire (CQLQ), has received $ 815 in the past 3 years from grant-funded investigators who used the CQLQ as an outcome measure in their study, outside of this work. Publisher Copyright: {\textcopyright} 2019 American Academy of Allergy, Asthma & Immunology",
year = "2019",
month = jul,
day = "1",
doi = "10.1016/j.jaip.2019.04.009",
language = "English (US)",
volume = "7",
pages = "1750--1755",
journal = "Journal of Allergy and Clinical Immunology: In Practice",
issn = "2213-2198",
publisher = "Elsevier",
number = "6",
}