Otitis media and the immotile cilia syndrome

Robert Jahrsdoerfer, Phillip S. Feldman, Edwin W. Rubel, John L. Guerrant, Peyton A. Eggleston, Robert F. Selden

Research output: Contribution to journalArticle

Abstract

The immotile cilia syndrome appears to be a congenital defect in the ultrastructure of cilia that renders them incapable of movement. Respiratory tract cilia and sperm are predominantly affected. Bronchiectasis, sinusitis and male sterility are the main clinical findings. Situs inversus may be found. To these findings can be added otitis media. The defect appears to be a complete or partial absence of dynein arms which are believed to be essential for generating movement of cilia or sperm tails. Six patients suspected of having immotile cilia were compared to six patients in a control group. In affected patients, no cilia movement in the middle ear or nasopharynx was observed using the operating microscope. Electron microscopy of cilia from the mucosa of the middle ear and nasopharynx appeared to confirm the ultrastructural defect in two of six patients suspected of having the syndrome.

Original languageEnglish (US)
Pages (from-to)769-778
Number of pages10
JournalLaryngoscope
Volume89
Issue number5
StatePublished - 1979
Externally publishedYes

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Ciliary Motility Disorders
Cilia
Otitis Media
Nasopharynx
Middle Ear
Sperm Tail
Situs Inversus
Dyneins
Bronchiectasis
Male Infertility
Sinusitis
Respiratory System
Spermatozoa
Electron Microscopy
Mucous Membrane
Arm
Control Groups

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Jahrsdoerfer, R., Feldman, P. S., Rubel, E. W., Guerrant, J. L., Eggleston, P. A., & Selden, R. F. (1979). Otitis media and the immotile cilia syndrome. Laryngoscope, 89(5), 769-778.

Otitis media and the immotile cilia syndrome. / Jahrsdoerfer, Robert; Feldman, Phillip S.; Rubel, Edwin W.; Guerrant, John L.; Eggleston, Peyton A.; Selden, Robert F.

In: Laryngoscope, Vol. 89, No. 5, 1979, p. 769-778.

Research output: Contribution to journalArticle

Jahrsdoerfer, R, Feldman, PS, Rubel, EW, Guerrant, JL, Eggleston, PA & Selden, RF 1979, 'Otitis media and the immotile cilia syndrome', Laryngoscope, vol. 89, no. 5, pp. 769-778.
Jahrsdoerfer R, Feldman PS, Rubel EW, Guerrant JL, Eggleston PA, Selden RF. Otitis media and the immotile cilia syndrome. Laryngoscope. 1979;89(5):769-778.
Jahrsdoerfer, Robert ; Feldman, Phillip S. ; Rubel, Edwin W. ; Guerrant, John L. ; Eggleston, Peyton A. ; Selden, Robert F. / Otitis media and the immotile cilia syndrome. In: Laryngoscope. 1979 ; Vol. 89, No. 5. pp. 769-778.
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