Abstract
Parathyroid hormone (PTH) secretion is regulated by a complex interplay of circulating minerals and hormones that include extracellular calcium (via the calcium-sensing receptor, CaSR), plasma phosphate, 1,25-dihydroxyvitamin D (1,25(OH)2D), and fibroblast growth factor 23 (FGF23). The most common causes of secondary hyperparathyroidism are renal disease and vitamin D deficiency. Although less common, other conditions that cause secondary hyperparathyroidism include disorders of calcium balance (deficiency, malabsorption, and excess excretion), disorders associated with FGF23 excess, persistent parathyroid disease after renal transplant, specific disorders of acid-base balance, and ingestion of certain medications.
Original language | English (US) |
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Title of host publication | The Parathyroids |
Subtitle of host publication | Basic and Clinical Concepts: Third Edition |
Publisher | Elsevier Inc. |
Pages | 671-684 |
Number of pages | 14 |
ISBN (Print) | 9780123971661 |
DOIs | |
State | Published - Jan 1 2015 |
Keywords
- Autosomal dominant hypophosphatemic rickets (ADHR)
- Bone mineral density (BMD)
- Calcium
- Calcium-phosphate balance
- Fibroblast growth factor 23 (FGF23)
- Hypercalciuria
- Rickets
- Tumor-induced osteomalacia (TIO)
ASJC Scopus subject areas
- General Medicine