O2 Sensing: Only Skin Deep?

Research output: Contribution to journalShort surveypeer-review

22 Scopus citations


The transcription factor HIF-1 mediates adaptive responses to hypoxia, and its activity is negatively regulated by O2-dependent binding of the von Hippel-Lindau (VHL) protein. In this issue, Boutin et al. (2008) use conditional knockout mice to demonstrate that sensing of O2 by keratinocytes in the epidermis leads to alterations in cutaneous blood flow that affect the production of the hormone erythropoietin, thereby modulating red blood cell production and the O2-carrying capacity of blood.

Original languageEnglish (US)
Pages (from-to)206-208
Number of pages3
Issue number2
StatePublished - Apr 18 2008

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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