Osteoporosis in Men and Women

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter explores gender differences in skeletal physiology, epidemiology of osteoporosis, causes of osteoporosis, evaluation of osteoporosis, and treatment of osteoporosis. Osteoporosis is more common amongst women than men. Women have lower peak bone mass, smaller bone size, go through menopause (a period of accelerated bone loss), and have greater longevity when compared to men. The lifetime risk of osteoporotic fracture at any site in women is as high as 40-50%. The morbidity and mortality sustained from fractures and osteoporosis in men does not completely parallel that of women. Men, too, report a distinct decline in quality of life following a vertebral or hip fracture, with 50% failing to regain their independence and mobility. Men also suffer a 25% mortality rate within the year following hip fracture. Current osteoporosis therapies have been well tested in women but variably tested in men, forcing the generalization that most therapies appear to be effective in both genders. Without question, understanding the distinct, gender-specific physiology of bone formation in men and women will lead to therapies that are tailored to address these skeletal differences and improve outcomes.

Original languageEnglish (US)
Title of host publicationPrinciples of Gender-Specific Medicine
PublisherElsevier Inc.
Pages716-736
Number of pages21
ISBN (Print)9780123742711
DOIs
StatePublished - 2010

Fingerprint

Osteoporosis
Hip Fractures
Bone and Bones
Osteoporotic Fractures
Mortality
Therapeutics
Menopause
Osteogenesis
Epidemiology
Quality of Life
Morbidity

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

Cite this

Moseley, K., & Jan De Beur, S. M. (2010). Osteoporosis in Men and Women. In Principles of Gender-Specific Medicine (pp. 716-736). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374271-1.00059-9

Osteoporosis in Men and Women. / Moseley, Kendall; Jan De Beur, Suzanne M.

Principles of Gender-Specific Medicine. Elsevier Inc., 2010. p. 716-736.

Research output: Chapter in Book/Report/Conference proceedingChapter

Moseley, K & Jan De Beur, SM 2010, Osteoporosis in Men and Women. in Principles of Gender-Specific Medicine. Elsevier Inc., pp. 716-736. https://doi.org/10.1016/B978-0-12-374271-1.00059-9
Moseley K, Jan De Beur SM. Osteoporosis in Men and Women. In Principles of Gender-Specific Medicine. Elsevier Inc. 2010. p. 716-736 https://doi.org/10.1016/B978-0-12-374271-1.00059-9
Moseley, Kendall ; Jan De Beur, Suzanne M. / Osteoporosis in Men and Women. Principles of Gender-Specific Medicine. Elsevier Inc., 2010. pp. 716-736
@inbook{32262954d12c42ccb93368e2f5d3403d,
title = "Osteoporosis in Men and Women",
abstract = "This chapter explores gender differences in skeletal physiology, epidemiology of osteoporosis, causes of osteoporosis, evaluation of osteoporosis, and treatment of osteoporosis. Osteoporosis is more common amongst women than men. Women have lower peak bone mass, smaller bone size, go through menopause (a period of accelerated bone loss), and have greater longevity when compared to men. The lifetime risk of osteoporotic fracture at any site in women is as high as 40-50{\%}. The morbidity and mortality sustained from fractures and osteoporosis in men does not completely parallel that of women. Men, too, report a distinct decline in quality of life following a vertebral or hip fracture, with 50{\%} failing to regain their independence and mobility. Men also suffer a 25{\%} mortality rate within the year following hip fracture. Current osteoporosis therapies have been well tested in women but variably tested in men, forcing the generalization that most therapies appear to be effective in both genders. Without question, understanding the distinct, gender-specific physiology of bone formation in men and women will lead to therapies that are tailored to address these skeletal differences and improve outcomes.",
author = "Kendall Moseley and {Jan De Beur}, {Suzanne M}",
year = "2010",
doi = "10.1016/B978-0-12-374271-1.00059-9",
language = "English (US)",
isbn = "9780123742711",
pages = "716--736",
booktitle = "Principles of Gender-Specific Medicine",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Osteoporosis in Men and Women

AU - Moseley, Kendall

AU - Jan De Beur, Suzanne M

PY - 2010

Y1 - 2010

N2 - This chapter explores gender differences in skeletal physiology, epidemiology of osteoporosis, causes of osteoporosis, evaluation of osteoporosis, and treatment of osteoporosis. Osteoporosis is more common amongst women than men. Women have lower peak bone mass, smaller bone size, go through menopause (a period of accelerated bone loss), and have greater longevity when compared to men. The lifetime risk of osteoporotic fracture at any site in women is as high as 40-50%. The morbidity and mortality sustained from fractures and osteoporosis in men does not completely parallel that of women. Men, too, report a distinct decline in quality of life following a vertebral or hip fracture, with 50% failing to regain their independence and mobility. Men also suffer a 25% mortality rate within the year following hip fracture. Current osteoporosis therapies have been well tested in women but variably tested in men, forcing the generalization that most therapies appear to be effective in both genders. Without question, understanding the distinct, gender-specific physiology of bone formation in men and women will lead to therapies that are tailored to address these skeletal differences and improve outcomes.

AB - This chapter explores gender differences in skeletal physiology, epidemiology of osteoporosis, causes of osteoporosis, evaluation of osteoporosis, and treatment of osteoporosis. Osteoporosis is more common amongst women than men. Women have lower peak bone mass, smaller bone size, go through menopause (a period of accelerated bone loss), and have greater longevity when compared to men. The lifetime risk of osteoporotic fracture at any site in women is as high as 40-50%. The morbidity and mortality sustained from fractures and osteoporosis in men does not completely parallel that of women. Men, too, report a distinct decline in quality of life following a vertebral or hip fracture, with 50% failing to regain their independence and mobility. Men also suffer a 25% mortality rate within the year following hip fracture. Current osteoporosis therapies have been well tested in women but variably tested in men, forcing the generalization that most therapies appear to be effective in both genders. Without question, understanding the distinct, gender-specific physiology of bone formation in men and women will lead to therapies that are tailored to address these skeletal differences and improve outcomes.

UR - http://www.scopus.com/inward/record.url?scp=84882487122&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882487122&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-374271-1.00059-9

DO - 10.1016/B978-0-12-374271-1.00059-9

M3 - Chapter

AN - SCOPUS:84882487122

SN - 9780123742711

SP - 716

EP - 736

BT - Principles of Gender-Specific Medicine

PB - Elsevier Inc.

ER -