Osteopontin and Systemic Lupus Erythematous association: A probable gene-gender interaction

Shizhong Han, Joel M. Guthridge, I. T W Harley, Andrea L. Sestak, Xana Kim-Howard, Kenneth M. Kaufman, Bahram Namjou, Harshal Deshmukh, Gail Bruner, Luis R. Espinoza, Gary S. Gilkeson, John B. Harley, Judith A. James, Swapan K. Nath

Research output: Contribution to journalArticle

Abstract

Osteopontin (SPP1) is an important bone matrix mediator found to have key roles in inflammation and immunity. SPP1 genetic polymorphisms and increased osteopontin protein levels have been reported to be associated with SLE in small patient collections. The present study evaluates association between SPP1 polymorphisms and SLE in a large cohort of 1141 unrelated SLE patients [707 European-American (EA) and 434 African-American (AA)], and 2009 unrelated controls (1309 EA and 700 AA). Population-based case-control association analyses were performed. To control for potential population stratification, admixture adjusted logistic regression, genomic control (GC), structured association (STRAT), and principal components analysis (PCA) were applied. Combined analysis of 2 ethnic groups, showed the minor allele of 2 SNPs (rs1126616T and rs9138C) significantly associated with higher risk of SLE in males (P=0.0005, OR=1.73, 95% Cl=1.28-2.33), but not in females. Indeed, significant gene-gender interactions in the 2 SNPs, rs1126772 and rs9138, were detected (P=0.001 and P=0.0006, respectively), Further, haplotype analysis identified rs1126616T-rs1126772A-rs9138C which demonstrated significant association with SLE in general (P=0.02, OR=1.30, 95% Cl 1.08-1.57), especially in males (P=0.0003, OR=2.42, 95% Cl 1.51-3.89). Subgroup analysis with single SNPs and haplotypes also identified a similar pattern of gender-specific association in AA and EA. GC, STRAT, and PCA results within each group showed consistent associations. Our data suggest SPP1 is associated with SLE, and this association is especially stronger in males. To our knowledge, this report serves as the first association of a specific autosomal gene with human male lupus.

Original languageEnglish (US)
Article numbere1757
JournalPLoS One
Volume3
Issue number3
DOIs
StatePublished - Mar 12 2008
Externally publishedYes

Fingerprint

osteopontin
Osteopontin
African Americans
Genes
Single Nucleotide Polymorphism
gender
Principal Component Analysis
Haplotypes
haplotypes
principal component analysis
Polymorphism
genes
Principal component analysis
genetic polymorphism
genomics
Bone Matrix
Genetic Polymorphisms
nationalities and ethnic groups
Ethnic Groups
Population

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Han, S., Guthridge, J. M., Harley, I. T. W., Sestak, A. L., Kim-Howard, X., Kaufman, K. M., ... Nath, S. K. (2008). Osteopontin and Systemic Lupus Erythematous association: A probable gene-gender interaction. PLoS One, 3(3), [e1757]. https://doi.org/10.1371/journal.pone.0001757

Osteopontin and Systemic Lupus Erythematous association : A probable gene-gender interaction. / Han, Shizhong; Guthridge, Joel M.; Harley, I. T W; Sestak, Andrea L.; Kim-Howard, Xana; Kaufman, Kenneth M.; Namjou, Bahram; Deshmukh, Harshal; Bruner, Gail; Espinoza, Luis R.; Gilkeson, Gary S.; Harley, John B.; James, Judith A.; Nath, Swapan K.

In: PLoS One, Vol. 3, No. 3, e1757, 12.03.2008.

Research output: Contribution to journalArticle

Han, S, Guthridge, JM, Harley, ITW, Sestak, AL, Kim-Howard, X, Kaufman, KM, Namjou, B, Deshmukh, H, Bruner, G, Espinoza, LR, Gilkeson, GS, Harley, JB, James, JA & Nath, SK 2008, 'Osteopontin and Systemic Lupus Erythematous association: A probable gene-gender interaction', PLoS One, vol. 3, no. 3, e1757. https://doi.org/10.1371/journal.pone.0001757
Han S, Guthridge JM, Harley ITW, Sestak AL, Kim-Howard X, Kaufman KM et al. Osteopontin and Systemic Lupus Erythematous association: A probable gene-gender interaction. PLoS One. 2008 Mar 12;3(3). e1757. https://doi.org/10.1371/journal.pone.0001757
Han, Shizhong ; Guthridge, Joel M. ; Harley, I. T W ; Sestak, Andrea L. ; Kim-Howard, Xana ; Kaufman, Kenneth M. ; Namjou, Bahram ; Deshmukh, Harshal ; Bruner, Gail ; Espinoza, Luis R. ; Gilkeson, Gary S. ; Harley, John B. ; James, Judith A. ; Nath, Swapan K. / Osteopontin and Systemic Lupus Erythematous association : A probable gene-gender interaction. In: PLoS One. 2008 ; Vol. 3, No. 3.
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