Osteonecrosis in pediatric cancer survivors: Epidemiology, risk factors, and treatment

Sandesh S. Rao; Jad M. El Abiad; Varun Puvanesarajah; Adam S. Levin; Lynne C. Jones; Carol D. Morris

doi:10.1016/j.suronc.2019.02.001

Osteonecrosis in pediatric cancer survivors: Epidemiology, risk factors, and treatment

Sandesh S. Rao, Jad M. El Abiad, Varun Puvanesarajah, Adam S. Levin, Lynne C. Jones, Carol D. Morris

School of Medicine

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Several treatment regimens for childhood malignancies have been associated with the development of osteonecrosis, including radiation therapy, glucocorticoid medications, immunotherapy (including anti-angiogenic agents), and several chemotherapeutic agents. Adolescents older than 10 years are at greatest risk of developing osteonecrosis within 1 year of initiating therapy. Screening with magnetic resonance imaging in this high-risk population may be a useful method for detecting osteonecrosis. Surgery may be required for lesions that have progressed substantially despite nonoperative interventions.

Original language	English (US)
Pages (from-to)	214-221
Number of pages	8
Journal	Surgical Oncology
Volume	28
DOIs	https://doi.org/10.1016/j.suronc.2019.02.001
State	Published - Mar 2019

Keywords

Chemotherapy
Late effects
Osteonecrosis
Pediatric cancer
Radiation

ASJC Scopus subject areas

Surgery
Oncology

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10.1016/j.suronc.2019.02.001

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title = "Osteonecrosis in pediatric cancer survivors: Epidemiology, risk factors, and treatment",

abstract = "Several treatment regimens for childhood malignancies have been associated with the development of osteonecrosis, including radiation therapy, glucocorticoid medications, immunotherapy (including anti-angiogenic agents), and several chemotherapeutic agents. Adolescents older than 10 years are at greatest risk of developing osteonecrosis within 1 year of initiating therapy. Screening with magnetic resonance imaging in this high-risk population may be a useful method for detecting osteonecrosis. Surgery may be required for lesions that have progressed substantially despite nonoperative interventions.",

keywords = "Chemotherapy, Late effects, Osteonecrosis, Pediatric cancer, Radiation",

author = "Rao, {Sandesh S.} and {El Abiad}, {Jad M.} and Varun Puvanesarajah and Levin, {Adam S.} and Jones, {Lynne C.} and Morris, {Carol D.}",

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year = "2019",

month = mar,

doi = "10.1016/j.suronc.2019.02.001",

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T1 - Osteonecrosis in pediatric cancer survivors

T2 - Epidemiology, risk factors, and treatment

AU - Rao, Sandesh S.

AU - El Abiad, Jad M.

AU - Puvanesarajah, Varun

AU - Levin, Adam S.

AU - Jones, Lynne C.

AU - Morris, Carol D.

PY - 2019/3

Y1 - 2019/3

N2 - Several treatment regimens for childhood malignancies have been associated with the development of osteonecrosis, including radiation therapy, glucocorticoid medications, immunotherapy (including anti-angiogenic agents), and several chemotherapeutic agents. Adolescents older than 10 years are at greatest risk of developing osteonecrosis within 1 year of initiating therapy. Screening with magnetic resonance imaging in this high-risk population may be a useful method for detecting osteonecrosis. Surgery may be required for lesions that have progressed substantially despite nonoperative interventions.

AB - Several treatment regimens for childhood malignancies have been associated with the development of osteonecrosis, including radiation therapy, glucocorticoid medications, immunotherapy (including anti-angiogenic agents), and several chemotherapeutic agents. Adolescents older than 10 years are at greatest risk of developing osteonecrosis within 1 year of initiating therapy. Screening with magnetic resonance imaging in this high-risk population may be a useful method for detecting osteonecrosis. Surgery may be required for lesions that have progressed substantially despite nonoperative interventions.

KW - Chemotherapy

KW - Late effects

KW - Osteonecrosis

KW - Pediatric cancer

KW - Radiation

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DO - 10.1016/j.suronc.2019.02.001

M3 - Review article

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AN - SCOPUS:85061672924

SN - 0960-7404

VL - 28

SP - 214

EP - 221

JO - Surgical Oncology

JF - Surgical Oncology

ER -

Osteonecrosis in pediatric cancer survivors: Epidemiology, risk factors, and treatment

Abstract

Keywords

ASJC Scopus subject areas

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