Osteoblastic metastases from astrocytomas: A report of two cases

D. C. Longee, H. S. Friedman, P. C. Phillips, P. C. Burger, W. J. Oakes, D. Heffez, M. Wharam, L. Strauss, G. N. Fuller, S. C. Schold

Research output: Contribution to journalArticle

Abstract

The spread of primary central nervous system (CNS) neoplasms beyond the confines of the neuraxis is a relatively uncommon observation. Extraneural metastases involving bone are quite rare, and have been observed almost exclusively in cases of medulloblastoma, high-grade (III-IV) astrocytoma, and glioblastoma multiforme. To date there has been only one case reported of bone metastasis from a ''well-differentiated'' astrocytoma. We now report two cases of astrocytoma in children with diffuse osteoblastic metastases and a fulminant clinical course. These cases demonstrate that due to the potential morphologic heterogeneity of these neoplasms, an initial biopsy diagnosis of low-grade astrocytoma does not always imply a benign clinical course.

Original languageEnglish (US)
Pages (from-to)318-324
Number of pages7
JournalMedical and Pediatric Oncology
Volume19
Issue number4
StatePublished - 1991

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Astrocytoma
Neoplasm Metastasis
Glioblastoma
Bone and Bones
Central Nervous System Neoplasms
Medulloblastoma
Observation
Biopsy
Neoplasms

Keywords

  • Bone metastasis
  • Computed tomography
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pediatrics, Perinatology, and Child Health

Cite this

Longee, D. C., Friedman, H. S., Phillips, P. C., Burger, P. C., Oakes, W. J., Heffez, D., ... Schold, S. C. (1991). Osteoblastic metastases from astrocytomas: A report of two cases. Medical and Pediatric Oncology, 19(4), 318-324.

Osteoblastic metastases from astrocytomas : A report of two cases. / Longee, D. C.; Friedman, H. S.; Phillips, P. C.; Burger, P. C.; Oakes, W. J.; Heffez, D.; Wharam, M.; Strauss, L.; Fuller, G. N.; Schold, S. C.

In: Medical and Pediatric Oncology, Vol. 19, No. 4, 1991, p. 318-324.

Research output: Contribution to journalArticle

Longee, DC, Friedman, HS, Phillips, PC, Burger, PC, Oakes, WJ, Heffez, D, Wharam, M, Strauss, L, Fuller, GN & Schold, SC 1991, 'Osteoblastic metastases from astrocytomas: A report of two cases', Medical and Pediatric Oncology, vol. 19, no. 4, pp. 318-324.
Longee DC, Friedman HS, Phillips PC, Burger PC, Oakes WJ, Heffez D et al. Osteoblastic metastases from astrocytomas: A report of two cases. Medical and Pediatric Oncology. 1991;19(4):318-324.
Longee, D. C. ; Friedman, H. S. ; Phillips, P. C. ; Burger, P. C. ; Oakes, W. J. ; Heffez, D. ; Wharam, M. ; Strauss, L. ; Fuller, G. N. ; Schold, S. C. / Osteoblastic metastases from astrocytomas : A report of two cases. In: Medical and Pediatric Oncology. 1991 ; Vol. 19, No. 4. pp. 318-324.
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