Osteoblast menin regulates bone mass in vivo

Ippei Kanazawa, Lucie Canaff, Jad Abi Rafeh, Aarti Angrula, Jingjing Li, Ryan C. Riddle, Iris Boraschi-Diaz, Svetlana V. Komarova, Thomas L. Clemens, Monzur Murshed, Geoffrey N. Hendy

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Constitutive homozygous Men1-/- mice at mid-gestation are small with craniofacial defects. Results: Conditional osteoblast Men1 knock-out mice have reduced bone mass, and transgenic osteoblast menin-overexpressing mice have increased bone mass. Conclusion: Knock-out mice menin-deficient primary osteoblasts have impaired mineralization and reduced responsiveness to TGF-β and BMP-2. Significance: Menin is a potential target for gain of function therapeutics in low bone mass disorders.

Original languageEnglish (US)
Pages (from-to)3910-3924
Number of pages15
JournalJournal of Biological Chemistry
Volume290
Issue number7
DOIs
StatePublished - Feb 13 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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