Osteoarthritis: Understanding the pathophysiology, genetics, and treatments

Vladamir Sinkov, Tyler Cymet

Research output: Contribution to journalReview articlepeer-review


Risk factors for developing osteoarthritis include age, previous joint injury, obesity, and a genetic predisposition. An imbalance of joint functioning initiates the disease process, which is then worsened through biochemical changes in the collagen in the joint. Joint pain is the cardinal clinical presentation. Radiographic and lab testing do not correlate well with the disease; therefore, diagnosis is made by clinical findings. Treatment focuses on maintaining joint function through the use of directed activity, physical therapy, and medications.

Original languageEnglish (US)
Pages (from-to)475-482
Number of pages8
JournalJournal of the National Medical Association
Issue number6
StatePublished - Jun 1 2003


  • Chondrocytes
  • Degenerative joint disease
  • Joint pain
  • Osteoarthritis
  • Osteophyte
  • Osteotomy
  • Subluxation
  • Symptomatic slow acting drugs for osteoarthritis (SYSADOA)

ASJC Scopus subject areas

  • Medicine(all)


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