Osteoarthritis: Genetic factors, animal models, mechanisms, and therapies

Qin Bian, Yong Jun Wang, Shu Fen Liu, Yi Ping Li

Research output: Contribution to journalArticle

Abstract

Osteoarthritis (OA) is the most common form of joint disease. OA frequently affects knees, hips, hands, and the spine. It is characterized by the progressive destruction of articular cartilage and subchondral bone accompanied by low-grade inflammation that together result in pain and deformity. Recent studies have shed light on the nature of OA genetic susceptibility and confirmed a number of candidate genes involved in the destruction of the synovium, articular cartilage, and subchondral bone in OA pathogenesis. During the progression of OA, there are several cellular changes in joints, including an increase in the number of activated osteoclasts and macrophages and an infiltration of the synovium by activated T-cells and Bcells. Pro-inflammatory mediators (e.g. interleukin IL-1, IL-1beta, IL-6, IL-17, and IL-18, and Tumor necrosis actor-alpha), proteinases (e.g. matrix metalloproteinase 9 and cathepsin K), and regulators of cartilage and bone formation (e.g. BMPs) have been shown to have important roles in OA progression at the molecular level. Studies have suggested that OA shares several common characteristics with rheumatoid arthritis (RA). To systematically understand OA, this review summarizes OA disease genes, mouse models of human disease experimental mouse models, mechanisms of OA pathogenesis, and current OA therapies.

Original languageEnglish (US)
Pages (from-to)74-100
Number of pages27
JournalFrontiers in Bioscience - Elite
Volume4 E
Issue number1
StatePublished - Jan 1 2012
Externally publishedYes

Fingerprint

Cartilage
Osteoarthritis
Bone
Animals
Animal Models
Genes
Cathepsin K
Interleukin-18
T-cells
Interleukin-17
Macrophages
Interleukins
Matrix Metalloproteinase 9
Interleukin-1
Infiltration
Tumors
Interleukin-6
Peptide Hydrolases
Therapeutics
Synovial Membrane

Keywords

  • Animal model
  • Articular cartilage
  • BMPs
  • Gene
  • Mechanisms
  • Osteoarthritis
  • Review
  • Subchondral bone
  • Synovium
  • Therapies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Osteoarthritis : Genetic factors, animal models, mechanisms, and therapies. / Bian, Qin; Wang, Yong Jun; Liu, Shu Fen; Li, Yi Ping.

In: Frontiers in Bioscience - Elite, Vol. 4 E, No. 1, 01.01.2012, p. 74-100.

Research output: Contribution to journalArticle

Bian, Qin ; Wang, Yong Jun ; Liu, Shu Fen ; Li, Yi Ping. / Osteoarthritis : Genetic factors, animal models, mechanisms, and therapies. In: Frontiers in Bioscience - Elite. 2012 ; Vol. 4 E, No. 1. pp. 74-100.
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