Oscillatory EEG activity induced by conditioning stimuli during fear conditioning reflects Salience and Valence of these stimuli more than Expectancy

J. H. Chien, L. Colloca, Anna Korzeniewska, J. J. Cheng, Claudia Campbell, Argye Hillis-Trupe, Frederick Lenz

Research output: Contribution to journalArticle

Abstract

Imaging studies have described hemodynamic activity during fear conditioning protocols with stimulus trains in which a visual conditioned stimulus (CS+) is paired with an aversive unconditioned stimulus (US, painful laser pulse) while another visual stimulus is unpaired (CS−). We now test the hypothesis that CS Event Related Spectral Perturbations (ERSPs) are related to ratings of CS Expectancy (likelihood of pairing with the US), Valence (unpleasantness) and Salience (ability to capture attention). ERSP windows in EEG were defined by both time after the CS and frequency, and showed increased oscillatory power (Event Related Synchronization, ERS) in the Delta/Theta Windows (0–8 Hz) and the Gamma Window (30–55 Hz). Decreased oscillatory power (Event Related Desynchronization – ERD) was found in Alpha (8–14 Hz) and Beta Windows (14–30 Hz). The Delta/Theta ERS showed a differential effect of CS+ versus CS− at Prefrontal, Frontal and Midline Channels, while Alpha and Beta ERD were greater at Parietal and Occipital Channels early in the stimulus train. The Gamma ERS Window increased from habituation to acquisition over a broad area from frontal and occipital electrodes. The CS Valence and Salience were greater for CS+ than CS−, and were correlated with each other and with the ERD at overlapping channels, particularly in the Alpha Window. Expectancy and CS Skin Conductance Response were greater for CS+ than CS− and were correlated with ERSP at fewer channels than Valence or Salience. These results suggest that Alpha ERSP activity during fear conditioning reflects Valence and Salience of the CSs more than conditioning per se.

Original languageEnglish (US)
Pages (from-to)81-93
Number of pages13
JournalNeuroscience
Volume346
DOIs
StatePublished - Mar 27 2017

Fingerprint

Fear
Electroencephalography
Aptitude
Electrodes
Lasers
Hemodynamics
Skin
Conditioning (Psychology)
Power (Psychology)

Keywords

  • EEG
  • event-related synchronization
  • fear conditioning
  • human
  • painful laser stimulus
  • salience

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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title = "Oscillatory EEG activity induced by conditioning stimuli during fear conditioning reflects Salience and Valence of these stimuli more than Expectancy",
abstract = "Imaging studies have described hemodynamic activity during fear conditioning protocols with stimulus trains in which a visual conditioned stimulus (CS+) is paired with an aversive unconditioned stimulus (US, painful laser pulse) while another visual stimulus is unpaired (CS−). We now test the hypothesis that CS Event Related Spectral Perturbations (ERSPs) are related to ratings of CS Expectancy (likelihood of pairing with the US), Valence (unpleasantness) and Salience (ability to capture attention). ERSP windows in EEG were defined by both time after the CS and frequency, and showed increased oscillatory power (Event Related Synchronization, ERS) in the Delta/Theta Windows (0–8 Hz) and the Gamma Window (30–55 Hz). Decreased oscillatory power (Event Related Desynchronization – ERD) was found in Alpha (8–14 Hz) and Beta Windows (14–30 Hz). The Delta/Theta ERS showed a differential effect of CS+ versus CS− at Prefrontal, Frontal and Midline Channels, while Alpha and Beta ERD were greater at Parietal and Occipital Channels early in the stimulus train. The Gamma ERS Window increased from habituation to acquisition over a broad area from frontal and occipital electrodes. The CS Valence and Salience were greater for CS+ than CS−, and were correlated with each other and with the ERD at overlapping channels, particularly in the Alpha Window. Expectancy and CS Skin Conductance Response were greater for CS+ than CS− and were correlated with ERSP at fewer channels than Valence or Salience. These results suggest that Alpha ERSP activity during fear conditioning reflects Valence and Salience of the CSs more than conditioning per se.",
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author = "Chien, {J. H.} and L. Colloca and Anna Korzeniewska and Cheng, {J. J.} and Claudia Campbell and Argye Hillis-Trupe and Frederick Lenz",
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T1 - Oscillatory EEG activity induced by conditioning stimuli during fear conditioning reflects Salience and Valence of these stimuli more than Expectancy

AU - Chien, J. H.

AU - Colloca, L.

AU - Korzeniewska, Anna

AU - Cheng, J. J.

AU - Campbell, Claudia

AU - Hillis-Trupe, Argye

AU - Lenz, Frederick

PY - 2017/3/27

Y1 - 2017/3/27

N2 - Imaging studies have described hemodynamic activity during fear conditioning protocols with stimulus trains in which a visual conditioned stimulus (CS+) is paired with an aversive unconditioned stimulus (US, painful laser pulse) while another visual stimulus is unpaired (CS−). We now test the hypothesis that CS Event Related Spectral Perturbations (ERSPs) are related to ratings of CS Expectancy (likelihood of pairing with the US), Valence (unpleasantness) and Salience (ability to capture attention). ERSP windows in EEG were defined by both time after the CS and frequency, and showed increased oscillatory power (Event Related Synchronization, ERS) in the Delta/Theta Windows (0–8 Hz) and the Gamma Window (30–55 Hz). Decreased oscillatory power (Event Related Desynchronization – ERD) was found in Alpha (8–14 Hz) and Beta Windows (14–30 Hz). The Delta/Theta ERS showed a differential effect of CS+ versus CS− at Prefrontal, Frontal and Midline Channels, while Alpha and Beta ERD were greater at Parietal and Occipital Channels early in the stimulus train. The Gamma ERS Window increased from habituation to acquisition over a broad area from frontal and occipital electrodes. The CS Valence and Salience were greater for CS+ than CS−, and were correlated with each other and with the ERD at overlapping channels, particularly in the Alpha Window. Expectancy and CS Skin Conductance Response were greater for CS+ than CS− and were correlated with ERSP at fewer channels than Valence or Salience. These results suggest that Alpha ERSP activity during fear conditioning reflects Valence and Salience of the CSs more than conditioning per se.

AB - Imaging studies have described hemodynamic activity during fear conditioning protocols with stimulus trains in which a visual conditioned stimulus (CS+) is paired with an aversive unconditioned stimulus (US, painful laser pulse) while another visual stimulus is unpaired (CS−). We now test the hypothesis that CS Event Related Spectral Perturbations (ERSPs) are related to ratings of CS Expectancy (likelihood of pairing with the US), Valence (unpleasantness) and Salience (ability to capture attention). ERSP windows in EEG were defined by both time after the CS and frequency, and showed increased oscillatory power (Event Related Synchronization, ERS) in the Delta/Theta Windows (0–8 Hz) and the Gamma Window (30–55 Hz). Decreased oscillatory power (Event Related Desynchronization – ERD) was found in Alpha (8–14 Hz) and Beta Windows (14–30 Hz). The Delta/Theta ERS showed a differential effect of CS+ versus CS− at Prefrontal, Frontal and Midline Channels, while Alpha and Beta ERD were greater at Parietal and Occipital Channels early in the stimulus train. The Gamma ERS Window increased from habituation to acquisition over a broad area from frontal and occipital electrodes. The CS Valence and Salience were greater for CS+ than CS−, and were correlated with each other and with the ERD at overlapping channels, particularly in the Alpha Window. Expectancy and CS Skin Conductance Response were greater for CS+ than CS− and were correlated with ERSP at fewer channels than Valence or Salience. These results suggest that Alpha ERSP activity during fear conditioning reflects Valence and Salience of the CSs more than conditioning per se.

KW - EEG

KW - event-related synchronization

KW - fear conditioning

KW - human

KW - painful laser stimulus

KW - salience

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