Orthostatic hypotension and the incidence of coronary heart disease: The atherosclerosis risk in communities study

Kathryn M. Rose, Herman A. Tyroler, Christopher J. Nardo, Donna K. Arnett, Kathleen C. Light, Wayne Rosamond, A. Richey Sharrett, Moyses Szklo

Research output: Contribution to journalArticle

Abstract

We examined the association between orthostatic hypotension (OH) at baseline examination (1987-1989) and the incidence of coronary heart disease (CHD) over an average of 6 years, among 12,433 black and white middle-aged men and women participating in the Atherosclerosis Risk in Communities (ARIC) study. OH was defined as a SBP decrease ≥ 20 mm Hg or a DBP decrease ≥ 10 mm Hg after changing from supine to standing. CHD events included definite or probable myocardial infarctions (MI), silent MI, and fatal CHD. Five percent of participants had OH. Prevalence increased with advancing age and was more common among those with cardiovascular disease (CVD)-related comorbidities and risk factors. Those with OH had an increased risk of CHD (hazard ratio [HR] = 3.49, 95% confidence interval [CI] = 2.58, 4.73). This association was attenuated after controlling for age, ethnicity, gender, comorbid conditions, and CVD risk factors (HR = 1.85, 95% CI = 1.31, 2.63).

Original languageEnglish (US)
Pages (from-to)571-578
Number of pages8
JournalAmerican Journal of Hypertension
Volume13
Issue number6 II SUPPL.
StatePublished - Dec 1 2000

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Keywords

  • CHD
  • Middle-age
  • Orthostatic hypotension

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Rose, K. M., Tyroler, H. A., Nardo, C. J., Arnett, D. K., Light, K. C., Rosamond, W., Sharrett, A. R., & Szklo, M. (2000). Orthostatic hypotension and the incidence of coronary heart disease: The atherosclerosis risk in communities study. American Journal of Hypertension, 13(6 II SUPPL.), 571-578.