Orthostatic change in blood pressure and incidence of atrial fibrillation: Results from a bi-ethnic population based study

Sunil K. Agarwal, Alvaro Alonso, Seamus Whelton, Elsayed Z. Soliman, Kathryn M. Rose, Alanna M. Chamberlain, Ross J. Simpson, Josef Coresh, Gerardo Heiss

Research output: Contribution to journalArticle

Abstract

Background: Autonomic fluctuations are associated with the initiation and possibly maintenance of atrial fibrillation (AF). However, little is known about the relationship between orthostatic blood pressure change, a common manifestation of autonomic dysfunction, and incident AF. Methods: We examined whether supine-to-standing changes in systolic blood pressure (SBP) are associated with incident AF in 12,071 African American and white men and women aged 45-64 years, enrolled in the Atherosclerosis Risks in Communities (ARIC) study. Orthostatic hypotension (OH) was defined as a supine-standing drop in SBP by ≥20 mmHg or diastolic blood pressure by ≥10 mmHg. AF cases were identified based on study scheduled 12-lead ECG, hospital discharge ICD codes, and death certificates through 2009. Results: OH was seen in 603 (5%) at baseline. During an average follow-up of 18.1 years, 1438 (11.9%) study participants developed AF. Incident AF occurred more commonly among those with OH than those without, a rate of 9.3 vs. 6.3 per 1000 person years, (p

Original languageEnglish (US)
Article numbere79030
JournalPLoS One
Volume8
Issue number11
DOIs
StatePublished - Nov 11 2013

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Blood pressure
Atrial Fibrillation
blood pressure
Blood Pressure
incidence
hypotension
Incidence
Orthostatic Hypotension
Population
systolic blood pressure
Electrocardiography
diastolic blood pressure
African Americans
Death Certificates
atherosclerosis
International Classification of Diseases
atrial fibrillation
Atherosclerosis
death
Maintenance

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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Orthostatic change in blood pressure and incidence of atrial fibrillation : Results from a bi-ethnic population based study. / Agarwal, Sunil K.; Alonso, Alvaro; Whelton, Seamus; Soliman, Elsayed Z.; Rose, Kathryn M.; Chamberlain, Alanna M.; Simpson, Ross J.; Coresh, Josef; Heiss, Gerardo.

In: PLoS One, Vol. 8, No. 11, e79030, 11.11.2013.

Research output: Contribution to journalArticle

Agarwal, Sunil K. ; Alonso, Alvaro ; Whelton, Seamus ; Soliman, Elsayed Z. ; Rose, Kathryn M. ; Chamberlain, Alanna M. ; Simpson, Ross J. ; Coresh, Josef ; Heiss, Gerardo. / Orthostatic change in blood pressure and incidence of atrial fibrillation : Results from a bi-ethnic population based study. In: PLoS One. 2013 ; Vol. 8, No. 11.
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