Orthologous gene-expression profiling in multi-species models: search for candidate genes.

Dmitry N. Grigoryev, Shwu Fan Ma, Rafael A. Irizarry, Shui Qing Ye, John Quackenbush, Joe G.N. Garcia

Research output: Contribution to journalArticlepeer-review

Abstract

Microarray-driven gene-expression profiles are generally produced and analyzed for a single specific experimental model. We have assessed an analytical approach that simultaneously evaluates multi-species experimental models within a particular biological condition using orthologous genes as linkers for the various Affymetrix microarray platforms on multi-species models of ventilator-associated lung injury. The results suggest that this approach may be a useful tool in the evaluation of biological processes of interest and selection of process-related candidate genes.

Original languageEnglish (US)
Pages (from-to)R34
JournalGenome biology
Volume5
Issue number5
StatePublished - 2004

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

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