Orthogonal time of flight cluster SIMS of biological samples

Agnès Tempez, Michael Ugarov, Hakim Bensaoula, Marc Gonin, Katrin Fuhrer, Valeri Raznikov, J. Albert Schultz, Yvon Le Beyec, Amina Woods

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The combination of cluster SIMS with an orthogonal time of flight (TOF) mass spectrometer was used for peptide structural analysis. Cluster SIMS were compared with MALDI for imaging biosurfaces. Beside the a, b, c and x, y, z fragments, cluster SIMS generated more internal fragments than MALDI. The technique was also found to be simpler for the analysis of cyclic peptides which required post source decay (PSD) MALDI. It was also useful for molecules which could not be desorbed as metastable ions or could not be enzymatically digested.

Original languageEnglish (US)
Title of host publicationProceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics
Pages761-762
Number of pages2
StatePublished - 2002
Externally publishedYes
EventProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States
Duration: Jun 2 2002Jun 6 2002

Other

OtherProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
CountryUnited States
CityOrlando, FL
Period6/2/026/6/02

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ASJC Scopus subject areas

  • Spectroscopy

Cite this

Tempez, A., Ugarov, M., Bensaoula, H., Gonin, M., Fuhrer, K., Raznikov, V., Schultz, J. A., Le Beyec, Y., & Woods, A. (2002). Orthogonal time of flight cluster SIMS of biological samples. In Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics (pp. 761-762)