Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes

Laurence Carroll, Romain Bejot, Rebekka Hueting, Robert King, Paul Bonnitcha, Simon Bayly, Martin Christlieb, Jonathan R. Dilworth, Antony D. Gee, Jérôme Declerck, Véronique Gouverneur

Research output: Contribution to journalArticle

Abstract

The synthesis of three pairs of orthogonally labelled fluorinated Cu bis(thiosemicarbazonato) complexes is presented. These are the first examples of 18F-labelled Cu(ii)-complexes designed to serve as new hypoxia selective PET tracers and as mechanistic probes to study the mode of action of this class of markers. In vitro evaluation revealed that the fluorinated Cu-complex derived from amide coupling is suitable for in vivo work.

Original languageEnglish (US)
Pages (from-to)4052-4054
Number of pages3
JournalChemical Communications
Volume46
Issue number23
DOIs
StatePublished - Jun 21 2010

    Fingerprint

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Carroll, L., Bejot, R., Hueting, R., King, R., Bonnitcha, P., Bayly, S., Christlieb, M., Dilworth, J. R., Gee, A. D., Declerck, J., & Gouverneur, V. (2010). Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes. Chemical Communications, 46(23), 4052-4054. https://doi.org/10.1039/b926980k