Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes

Laurence Carroll; Romain Bejot; Rebekka Hueting; Robert King; Paul Bonnitcha; Simon Bayly; Martin Christlieb; Jonathan R. Dilworth; Antony D. Gee; Jérôme Declerck; Véronique Gouverneur

doi:10.1039/b926980k

Orthogonal ¹⁸F and ⁶⁴Cu labelling of functionalised bis(thiosemicarbazonato) complexes

Laurence Carroll, Romain Bejot, Rebekka Hueting, Robert King, Paul Bonnitcha, Simon Bayly, Martin Christlieb, Jonathan R. Dilworth, Antony D. Gee, Jérôme Declerck, Véronique Gouverneur

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The synthesis of three pairs of orthogonally labelled fluorinated Cu bis(thiosemicarbazonato) complexes is presented. These are the first examples of ¹⁸F-labelled Cu(ii)-complexes designed to serve as new hypoxia selective PET tracers and as mechanistic probes to study the mode of action of this class of markers. In vitro evaluation revealed that the fluorinated Cu-complex derived from amide coupling is suitable for in vivo work.

Original language	English (US)
Pages (from-to)	4052-4054
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	23
DOIs	https://doi.org/10.1039/b926980k
State	Published - Jun 21 2010
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/b926980k

Cite this

@article{56469ff1ff0341e0aa94b4be78e890b2,

title = "Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes",

abstract = "The synthesis of three pairs of orthogonally labelled fluorinated Cu bis(thiosemicarbazonato) complexes is presented. These are the first examples of 18F-labelled Cu(ii)-complexes designed to serve as new hypoxia selective PET tracers and as mechanistic probes to study the mode of action of this class of markers. In vitro evaluation revealed that the fluorinated Cu-complex derived from amide coupling is suitable for in vivo work.",

author = "Laurence Carroll and Romain Bejot and Rebekka Hueting and Robert King and Paul Bonnitcha and Simon Bayly and Martin Christlieb and Dilworth, {Jonathan R.} and Gee, {Antony D.} and J{\'e}r{\^o}me Declerck and V{\'e}ronique Gouverneur",

year = "2010",

month = jun,

day = "21",

doi = "10.1039/b926980k",

language = "English (US)",

volume = "46",

pages = "4052--4054",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "23",

}

TY - JOUR

T1 - Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes

AU - Carroll, Laurence

AU - Bejot, Romain

AU - Hueting, Rebekka

AU - King, Robert

AU - Bonnitcha, Paul

AU - Bayly, Simon

AU - Christlieb, Martin

AU - Dilworth, Jonathan R.

AU - Gee, Antony D.

AU - Declerck, Jérôme

AU - Gouverneur, Véronique

PY - 2010/6/21

Y1 - 2010/6/21

N2 - The synthesis of three pairs of orthogonally labelled fluorinated Cu bis(thiosemicarbazonato) complexes is presented. These are the first examples of 18F-labelled Cu(ii)-complexes designed to serve as new hypoxia selective PET tracers and as mechanistic probes to study the mode of action of this class of markers. In vitro evaluation revealed that the fluorinated Cu-complex derived from amide coupling is suitable for in vivo work.

AB - The synthesis of three pairs of orthogonally labelled fluorinated Cu bis(thiosemicarbazonato) complexes is presented. These are the first examples of 18F-labelled Cu(ii)-complexes designed to serve as new hypoxia selective PET tracers and as mechanistic probes to study the mode of action of this class of markers. In vitro evaluation revealed that the fluorinated Cu-complex derived from amide coupling is suitable for in vivo work.

UR - http://www.scopus.com/inward/record.url?scp=77953194793&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953194793&partnerID=8YFLogxK

U2 - 10.1039/b926980k

DO - 10.1039/b926980k

M3 - Article

C2 - 20407674

AN - SCOPUS:77953194793

SN - 1359-7345

VL - 46

SP - 4052

EP - 4054

JO - Chemical Communications

JF - Chemical Communications

IS - 23

ER -

Orthogonal ¹⁸F and ⁶⁴Cu labelling of functionalised bis(thiosemicarbazonato) complexes

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this