Orthogonal diffusion-weighted MRI measures distinguish region-specific degeneration in cerebellar ataxia subtypes

Sarah H. Ying, Bennett A. Landman, Shwetadwip Chowdhury, Alexander H. Sinofsky, Anna Gambini, Susumu Mori, David S. Zee, Jerry L. Prince

Research output: Contribution to journalArticlepeer-review

Abstract

The cerebellar peduncles are excellent candidates for composite indicators of regional degeneration in posterior fossa structures, as the peduncles show histopathological changes in degenerative ataxia. We postulate that magnetic resonance imaging will reveal evidence of disease specific peduncle degeneration through macrostructural (cross-sectional area) and microstructural (fractional anisotropy, mean diffusivity) measures. This study presents a "proof of principle" using orthogonal diffusion tensor imaging cross-sections of the cerebellar peduncles to distinguish categories of cerebellar disease.

Original languageEnglish (US)
Pages (from-to)1939-1942
Number of pages4
JournalJournal of neurology
Volume256
Issue number11
DOIs
StatePublished - Nov 2009

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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