A total of 167 human immunodeficiency virus (HIV)-infected patients with oropharyngeal candidiasis were randomly assigned to receive 14 days of therapy with liquid suspension fluconazole (100 mg once daily) or liquid nystatin (500,000 U four times daily). At day 14, 87% of the fluconazole- treated patients were clinically cured, as opposed to 52% in the nystatin- treated group (P <.001). Fluconazole eradicated Candida organisms from the oral flora in 60%, vs. a 6% eradication rate with nystatin (P <.001). The fluconazole group had fewer relapses noted on day 28 (18%, vs. 44% in the nystatin group; P <.001). This relapse difference no longer existed by day 42. Fluconazole oral suspension as a systemic therapy was more effective than liquid nystatin as a topical therapy in the treatment of oral candidiasis in HIV-infected patients and provided a longer disease-free interval before relapse.
|Original language||English (US)|
|Number of pages||4|
|Journal||Clinical Infectious Diseases|
|State||Published - 1997|
ASJC Scopus subject areas