TY - JOUR
T1 - Oropharyngeal candidiasis in patients with AIDS
T2 - Randomized comparison of fluconazole versus nystatin oral suspensions
AU - Pons, Vincent
AU - Greenspan, Deborah
AU - Lozada-Nur, Francina
AU - McPhail, Laurie
AU - Gallant, Joel E.
AU - Tunkel, Allan
AU - Johnson, Caroline C.
AU - McCarty, James
AU - Panzer, Helene
AU - Levenstein, Marcia
AU - Barranco, Annclla
AU - Green, Stephen
PY - 1997
Y1 - 1997
N2 - A total of 167 human immunodeficiency virus (HIV)-infected patients with oropharyngeal candidiasis were randomly assigned to receive 14 days of therapy with liquid suspension fluconazole (100 mg once daily) or liquid nystatin (500,000 U four times daily). At day 14, 87% of the fluconazole- treated patients were clinically cured, as opposed to 52% in the nystatin- treated group (P <.001). Fluconazole eradicated Candida organisms from the oral flora in 60%, vs. a 6% eradication rate with nystatin (P <.001). The fluconazole group had fewer relapses noted on day 28 (18%, vs. 44% in the nystatin group; P <.001). This relapse difference no longer existed by day 42. Fluconazole oral suspension as a systemic therapy was more effective than liquid nystatin as a topical therapy in the treatment of oral candidiasis in HIV-infected patients and provided a longer disease-free interval before relapse.
AB - A total of 167 human immunodeficiency virus (HIV)-infected patients with oropharyngeal candidiasis were randomly assigned to receive 14 days of therapy with liquid suspension fluconazole (100 mg once daily) or liquid nystatin (500,000 U four times daily). At day 14, 87% of the fluconazole- treated patients were clinically cured, as opposed to 52% in the nystatin- treated group (P <.001). Fluconazole eradicated Candida organisms from the oral flora in 60%, vs. a 6% eradication rate with nystatin (P <.001). The fluconazole group had fewer relapses noted on day 28 (18%, vs. 44% in the nystatin group; P <.001). This relapse difference no longer existed by day 42. Fluconazole oral suspension as a systemic therapy was more effective than liquid nystatin as a topical therapy in the treatment of oral candidiasis in HIV-infected patients and provided a longer disease-free interval before relapse.
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M3 - Article
C2 - 9195083
AN - SCOPUS:0030927488
SN - 1058-4838
VL - 24
SP - 1204
EP - 1207
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 6
ER -