TY - JOUR
T1 - Ornithine decarboxylase is important in intestinal mucosal maturation and recovery from injury in rats
AU - Luk, Gordon D.
AU - Marton, Laurence J.
AU - Baylin, Stephen B.
PY - 1980
Y1 - 1980
N2 - A transient increase in ornithine decarboxylase activity and polyamine biosynthesis occurs in the intestinal mucosa of the newborn rat in the third week after birth. During this period, there is a rapid conversion of the mucosa from a fetal to a mature adult status. A similar increase in ornithine decarboxylase activity also ac-companies the rapid recovery of the mucosa 1 week after an injury is induced by chemotherapy in adult rats. In vivo, α-difluoromethyl ornithine, a highly selective, enzyme-activated, irreversible inhibitor, suppresses these increases in mucosal ornithine decarboxylase and delays both intestinal mucosal maturation and recovery from injury. Thus increased ornithine decarboxylase activity, with the resultant increase in polyamine content, may play an essential role in intestinal mucosal maturation and regeneration in the rat.
AB - A transient increase in ornithine decarboxylase activity and polyamine biosynthesis occurs in the intestinal mucosa of the newborn rat in the third week after birth. During this period, there is a rapid conversion of the mucosa from a fetal to a mature adult status. A similar increase in ornithine decarboxylase activity also ac-companies the rapid recovery of the mucosa 1 week after an injury is induced by chemotherapy in adult rats. In vivo, α-difluoromethyl ornithine, a highly selective, enzyme-activated, irreversible inhibitor, suppresses these increases in mucosal ornithine decarboxylase and delays both intestinal mucosal maturation and recovery from injury. Thus increased ornithine decarboxylase activity, with the resultant increase in polyamine content, may play an essential role in intestinal mucosal maturation and regeneration in the rat.
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U2 - 10.1126/science.6774420
DO - 10.1126/science.6774420
M3 - Article
C2 - 6774420
AN - SCOPUS:0019196424
SN - 0036-8075
VL - 210
SP - 195
EP - 198
JO - Science
JF - Science
IS - 4466
ER -