Ornithine decarboxylase: Inhibition by a-hydrazinoornithine

Sami I. Harik, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

a-Hydrazinoornithine is a potent inhibitor of ornithine decarboxylase (EC 4.1.1.17, l-ornithine carboxy-lyase) with Ki values for the enzyme from Escherichia coli and rat ventral prostate of 5 · 10-7 and 2·10-6 M, respectively. Inhibition of ornithine decarboxylase by a-hydrazinoornithine is relatively selective, since the drug is 1-2 orders of magnitude less potent in inhibiting other pyridoxal phosphate-dependent amino acid decarboxylases. Other hydrazino compounds examined are much less potent inhibitors of ornithine deacrboxylase than a-hydrazinoornithine. Inhibition by a-hydrazinoornithine is reversible and competitive with respect to substrate.

Original languageEnglish (US)
Pages (from-to)501-509
Number of pages9
JournalBBA - Enzymology
Volume327
Issue number2
DOIs
StatePublished - Dec 19 1973

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Ornithine Decarboxylase
Pyridoxal Phosphate
Ornithine
Carboxy-Lyases
Prostate
Escherichia coli
Amino Acids
Enzymes
Pharmaceutical Preparations

Cite this

Ornithine decarboxylase : Inhibition by a-hydrazinoornithine. / Harik, Sami I.; Snyder, Solomon H.

In: BBA - Enzymology, Vol. 327, No. 2, 19.12.1973, p. 501-509.

Research output: Contribution to journalArticle

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