Ornithine aminotransferase-related sequences map to two nonadjacent intervals on the human X chromosome short arm

Ronald G. Lafreniere, Michael T. Geraghty, David Valle, Thomas B. Shows, Huntington F. Willard

Research output: Contribution to journalArticle


Using a panel of human/rodent somatic cell hybrids segregating human X/autosome translocations and deletions, we have refined the localization of the X-linked sequences homologous to ornithine-δ-aminotransferase (OAT), the structural locus for which (OAT) maps to chromosome 10. OAT-related ("-like") (OATL) sequences mapped to two nonadjacent intervals: OATL1 mapped to Xp11.3-p11.23, while OATL2 mapped to Xp11.22-p11.21. X-linked OATL1 sequences polymorphic for ScaI and StuI map to the more distal interval in Xp11.3-p11.23. These results should help guide long-range cloning and mapping studies, as well as refine the genetic linkage map in this region of the X chromosome.

Original languageEnglish (US)
Pages (from-to)276-279
Number of pages4
Issue number1
Publication statusPublished - 1991


ASJC Scopus subject areas

  • Genetics

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