Ornithine aminotransferase-related sequences map to two nonadjacent intervals on the human X chromosome short arm

Ronald G. Lafreniere, Michael T. Geraghty, David Valle, Thomas B. Shows, Huntington F. Willard

Research output: Contribution to journalArticle

Abstract

Using a panel of human/rodent somatic cell hybrids segregating human X/autosome translocations and deletions, we have refined the localization of the X-linked sequences homologous to ornithine-δ-aminotransferase (OAT), the structural locus for which (OAT) maps to chromosome 10. OAT-related ("-like") (OATL) sequences mapped to two nonadjacent intervals: OATL1 mapped to Xp11.3-p11.23, while OATL2 mapped to Xp11.22-p11.21. X-linked OATL1 sequences polymorphic for ScaI and StuI map to the more distal interval in Xp11.3-p11.23. These results should help guide long-range cloning and mapping studies, as well as refine the genetic linkage map in this region of the X chromosome.

Original languageEnglish (US)
Pages (from-to)276-279
Number of pages4
JournalGenomics
Volume10
Issue number1
DOIs
StatePublished - 1991

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Ornithine-Oxo-Acid Transaminase
Chromosomes, Human, X
Chromosomes, Human, Pair 10
Genetic Linkage
Hybrid Cells
X Chromosome
Sequence Homology
Organism Cloning
Rodentia

ASJC Scopus subject areas

  • Genetics

Cite this

Ornithine aminotransferase-related sequences map to two nonadjacent intervals on the human X chromosome short arm. / Lafreniere, Ronald G.; Geraghty, Michael T.; Valle, David; Shows, Thomas B.; Willard, Huntington F.

In: Genomics, Vol. 10, No. 1, 1991, p. 276-279.

Research output: Contribution to journalArticle

Lafreniere, Ronald G. ; Geraghty, Michael T. ; Valle, David ; Shows, Thomas B. ; Willard, Huntington F. / Ornithine aminotransferase-related sequences map to two nonadjacent intervals on the human X chromosome short arm. In: Genomics. 1991 ; Vol. 10, No. 1. pp. 276-279.
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