Origin of multicellular eukaryotes - Insights from proteome comparisons

L. Aravind, G. Subramanian

Research output: Contribution to journalReview articlepeer-review


The complete genomes of the yeast Saccharomyces cerevisiae and the nematode worm Caenorhabditis elegans have recently become available allowing the comparison of the complete protein sets of a unicellular and multicellular eukaryote for the first time. These comparisons reveal some striking trends in terms of expansions or extensive shuffling of specific domains that are involved in regulatory functions and signaling. Similar comparisons with the available sequence data from the plant Arabidopsis thaliana produce consistent results. These observations have provided useful insights regarding the origin of multicellular organisms.

Original languageEnglish (US)
Pages (from-to)688-694
Number of pages7
JournalCurrent Opinion in Genetics and Development
Issue number6
StatePublished - Dec 1 1999

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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