Origin of colloid cyst: immunoperoxidase study

T. Shibata, P. C. Burger, P. Kleihues

Research output: Contribution to journalArticle

Abstract

Despite their consistent anatomic location and histological features, the histogenesis of colloid cysts has remained obscure. We report immunohistochemical data on surgically excised cysts in attempt to define the origin of the lining epithelial cells. Paraffin-embedded tissues from colloidal cysts (7 in the 3rd ventricle and one in the sella) and two similar epithelial cysts (one in the cerebellopontine angle and one in the sella) were investigated. After examination by conventional stains, immunoperoxidase studies were carried out using primary antisera against epithelial membrane antigen (EMA), tissue polypeptide antigen (TPA), epidermal keratin (EK) and S-100 protein. The apical plasma membrane, surface microstructures were consistently EMA positive. Columnar cells demonstrated cytoplasmic staining for TPA. Basal cells of lining epithelia expressed EK. All epithelia studied were negative for S-100 protein. These findings suggest an endodermal origin of colloid cysts.

Original languageEnglish (US)
Pages (from-to)953-958
Number of pages6
JournalBrain and Nerve
Volume39
Issue number10
StatePublished - Oct 1987
Externally publishedYes

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Colloid Cysts
Tissue Polypeptide Antigen
Cysts
Mucin-1
S100 Proteins
Keratins
Epithelium
Cerebellopontine Angle
Third Ventricle
Paraffin
Immune Sera
Coloring Agents
Epithelial Cells
Cell Membrane
Staining and Labeling
Membranes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Shibata, T., Burger, P. C., & Kleihues, P. (1987). Origin of colloid cyst: immunoperoxidase study. Brain and Nerve, 39(10), 953-958.

Origin of colloid cyst : immunoperoxidase study. / Shibata, T.; Burger, P. C.; Kleihues, P.

In: Brain and Nerve, Vol. 39, No. 10, 10.1987, p. 953-958.

Research output: Contribution to journalArticle

Shibata, T, Burger, PC & Kleihues, P 1987, 'Origin of colloid cyst: immunoperoxidase study', Brain and Nerve, vol. 39, no. 10, pp. 953-958.
Shibata T, Burger PC, Kleihues P. Origin of colloid cyst: immunoperoxidase study. Brain and Nerve. 1987 Oct;39(10):953-958.
Shibata, T. ; Burger, P. C. ; Kleihues, P. / Origin of colloid cyst : immunoperoxidase study. In: Brain and Nerve. 1987 ; Vol. 39, No. 10. pp. 953-958.
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