Origin of chromosome rearrangements in two long-lived human keratinocyte lines

C. Rosenberg; G. Stetten; W. G. Kearns; P. L. Pearson; J. W. Littlefield

doi:10.1007/BF02631249

Origin of chromosome rearrangements in two long-lived human keratinocyte lines

C. Rosenberg, G. Stetten, W. G. Kearns, P. L. Pearson, J. W. Littlefield

School of Medicine

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3 Scopus citations

Abstract

We have determined the origin of the extra chromosomal material in the karyotypes of two spontaneously-occurring long-lived human keratinocyte lines, HKC-N2 and HKC-N6. In each case the extra material was derived from the chromosome on which it was located. Possible relationships between the triplication of chromosomal material and the overcoming of cell senescence are discussed.

Original language	English (US)
Pages (from-to)	823-825
Number of pages	3
Journal	In Vitro Cellular and Developmental Biology - Animal
Volume	27 A
Issue number	10
DOIs	https://doi.org/10.1007/BF02631249
State	Published - 1991

ASJC Scopus subject areas

Developmental Biology
Clinical Biochemistry
Cell Biology

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10.1007/BF02631249

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title = "Origin of chromosome rearrangements in two long-lived human keratinocyte lines",

abstract = "We have determined the origin of the extra chromosomal material in the karyotypes of two spontaneously-occurring long-lived human keratinocyte lines, HKC-N2 and HKC-N6. In each case the extra material was derived from the chromosome on which it was located. Possible relationships between the triplication of chromosomal material and the overcoming of cell senescence are discussed.",

author = "C. Rosenberg and G. Stetten and Kearns, {W. G.} and Pearson, {P. L.} and Littlefield, {J. W.}",

year = "1991",

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T1 - Origin of chromosome rearrangements in two long-lived human keratinocyte lines

AU - Rosenberg, C.

AU - Stetten, G.

AU - Kearns, W. G.

AU - Pearson, P. L.

AU - Littlefield, J. W.

PY - 1991

Y1 - 1991

N2 - We have determined the origin of the extra chromosomal material in the karyotypes of two spontaneously-occurring long-lived human keratinocyte lines, HKC-N2 and HKC-N6. In each case the extra material was derived from the chromosome on which it was located. Possible relationships between the triplication of chromosomal material and the overcoming of cell senescence are discussed.

AB - We have determined the origin of the extra chromosomal material in the karyotypes of two spontaneously-occurring long-lived human keratinocyte lines, HKC-N2 and HKC-N6. In each case the extra material was derived from the chromosome on which it was located. Possible relationships between the triplication of chromosomal material and the overcoming of cell senescence are discussed.

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U2 - 10.1007/BF02631249

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AN - SCOPUS:0025751683

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JO - In Vitro Cellular and Developmental Biology - Animal

JF - In Vitro Cellular and Developmental Biology - Animal

IS - 10

ER -

Origin of chromosome rearrangements in two long-lived human keratinocyte lines

Abstract

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