Orientation dependence of microcirculation-induced diffusion signal in anisotropic tissues

Osama M. Abdullah, Arnold Gomez, Samer Merchant, Michael Heidinger, Steven Poelzing, Edward W. Hsu

Research output: Contribution to journalArticle

Abstract

Purpose: To seek a better understanding of the effect of organized capillary flow on the MR diffusion-weighted signal. Methods: A theoretical framework was proposed to describe the diffusion-weighted MR signal, which was then validated both numerically using a realistic model of capillary network and experimentally in an animal model of isolated perfused heart preparation with myocardial blood flow verified by means of direct arterial spin labeling measurements. Results: Microcirculation in organized tissues gave rise to an MR signal that could be described as a combination of the bi-exponential behavior of conventional intravoxel incoherent motion (IVIM) theory and diffusion tensor imaging (DTI) -like anisotropy of the vascular signal, with the flow-related pseudo diffusivity represented as the linear algebraic product between the encoding directional unit vector and an appropriate tensor entity. Very good agreement between theoretical predictions and both numerical and experimental observations were found. Conclusion: These findings suggest that the DTI formalism of anisotropic spin motion can be incorporated into the classical IVIM theory to describe the MR signal arising from diffusion and microcirculation in organized tissues. Magn Reson Med 76:1252–1262, 2016.

Original languageEnglish (US)
Pages (from-to)1252-1262
Number of pages11
JournalMagnetic resonance in medicine
Volume76
Issue number4
DOIs
StatePublished - Oct 1 2016
Externally publishedYes

Fingerprint

Microcirculation
Diffusion Tensor Imaging
Anisotropy
Blood Vessels
Animal Models

Keywords

  • anisotropic blood flow
  • apparent diffusion coefficient
  • diffusion-weighted MRI
  • IVIM
  • organized capillary flow
  • perfusion fraction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Orientation dependence of microcirculation-induced diffusion signal in anisotropic tissues. / Abdullah, Osama M.; Gomez, Arnold; Merchant, Samer; Heidinger, Michael; Poelzing, Steven; Hsu, Edward W.

In: Magnetic resonance in medicine, Vol. 76, No. 4, 01.10.2016, p. 1252-1262.

Research output: Contribution to journalArticle

Abdullah, Osama M. ; Gomez, Arnold ; Merchant, Samer ; Heidinger, Michael ; Poelzing, Steven ; Hsu, Edward W. / Orientation dependence of microcirculation-induced diffusion signal in anisotropic tissues. In: Magnetic resonance in medicine. 2016 ; Vol. 76, No. 4. pp. 1252-1262.
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