@article{05a368a2dae24917b9c45cbeed11ae4c,
title = "Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem",
abstract = "Glioblastoma is a very aggressive primary brain tumor in adults, with very low survival rates and no curative treatments. The high failure rate of drug development for this cancer is linked to the high-cost, time-consuming, and inefficient models used to study the disease. Advances in stem cell and in vitro cultures technologies are promising, however, and here we present the advantages and limitations of available organotypic culture models and discuss their possible applications for studying glioblastoma.",
keywords = "Bioengineering, Cancer, Clinical Neuroscience, Tissue Engineering",
author = "David Pamies and Zurich, {Marie Gabrielle} and Thomas Hartung",
note = "Funding Information: We are very thankful to Dr. Erika Cosset from Laboratory of tumor immunology, Faculty of Medicine, University of Geneva, for helping with our questions about their model. We acknowledge Michael Hughes for editing the manuscript. P.D. is financially supported by the Swiss Centre for Applied Human Toxicology (SCAHT), Switzerland. D.P. has written the first draft of the manuscript. T.H. and M.-G.Z. have revised, corrected, and improved the document substantially. T.H. and D.P. are named inventors on a patent by Johns Hopkins University on the production of mini-brains (also called BrainSpheres), which is licensed to AxoSim, New Orleans, LA, USA. They consult AxoSim, and T.H. is a shareholder. Funding Information: We are very thankful to Dr. Erika Cosset from Laboratory of tumor immunology, Faculty of Medicine, University of Geneva, for helping with our questions about their model. We acknowledge Michael Hughes for editing the manuscript. P.D. is financially supported by the Swiss Centre for Applied Human Toxicology (SCAHT), Switzerland. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = oct,
day = "23",
doi = "10.1016/j.isci.2020.101633",
language = "English (US)",
volume = "23",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "10",
}